HLA-E and HLA-G Typing
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		Major histocompatibility complex (MHC) class I human genes have been divided into two different subgroups. The classical class I loci, human leukocyte antigen (HLA)-A, -B and -C, encode highly polymorphic membrane glycoproteins. These proteins present intracellular-derived peptides to cytotoxic T cells (1  ) and are expressed in all nucleated cells. In contrast, the nonclassical class I genes encode molecules (class Ib molecules) that have only recently been defined and their functions are not fully understood (HLA-E, -F, and -G) (2  –10  ).







![PSMB9 LMP2=proteasome LMP2.s {alternatively spliced} [human, EBV-transformed B lymphoblastoid typing cell lines, mRNA, 645 nt].](https://img1.dxycdn.com/p/s14/2024/0514/752/2760093895118520971.jpg!wh200)



