Oxanosine

具有多种生物活性的鸟苷类似物；对多种细菌均有活性，包括S.flexneri、P.mirabilis和E.coli（在蛋白胨琼脂上，MIC分别为6.25、12.5、25µg/ml）；抑制受感染的CEM和U937细胞中HIV-1 IIIb的复制（EC50分别为7和27µg/ml）；抑制HeLa细胞的生长（IC50=32µg/ml）并降低小鼠L1210淋巴细胞白血病模型中的肿瘤生长。A guanosine analog with diverse biological activities; active against a variety of bacteria, including S. flexneri, P. mirabilis, and E. coli (MICs = 6.25, 12.5, 25 µg/ml, respectively, on peptone agar); inhibits replication of HIV-1 IIIb in infected CEM and U937 cells (EC50s = 7 and 27 µg/ml, respectively); inhibits the growth of HeLa cells (IC50 = 32 µg/ml) and reduces tumor growth in a murine L1210 lymphocytic leukemia model.分子式C10H12N4O6分子量284.2O=C1C2=C(N=C(O1)N)N([C@@]3([H])[C@H](O)[C@H](O)[C@@H](CO)O3)C=N2