Cirsimaritin

一种具有多种生物活性的黄酮；与大鼠腺苷A1、大鼠A2A和人类A3受体结合（在放射性配体结合试验中，Kis分别为1.2、3和1.72µM）；抑制DPP-4（IC50=0.43µM）；对恶性疟原虫NF54菌株有活性（IC50=16.9µM）；抑制AGS、HT-29、Saos-2和WEHI164细胞的增殖（IC50s分别为14.4、13.1、38.5和40.7µM）；在10mg/kg剂量下增加小鼠进入高架十字迷宫开放臂的次数和停留时间百分比。A flavone with diverse biological activities; binds to rat adenosine A1, rat A2A, and human A3 receptors (Kis = 1.2, 3, and 1.72 µM, respectively, in radioligand binding assays); inhibits DPP-4 (IC50 = 0.43 µM); active against the NF54 strain of P. falciparum (IC50 = 16.9 µM); inhibits proliferation of AGS, HT-29, Saos-2, and WEHI 164 cells (IC50s = 14.4, 13.1, 38.5, and 40.7 µM, respectively; increases the number of entries into, and percentage of time spent in, the open arms of the elevated plus maze in mice at 10 mg/kg.分子式C17H14O6分子量314.3O=C1C=C(C2=CC=C(C=C2)O)OC3=CC(OC)=C(C(O)=C13)OC