SMIFH2

FH2结构域抑制剂；抑制由小鼠forminmDia1(FH1FH2)介导的原肌动蛋白-肌动蛋白组装(IC50=~15μM)；抑制由mDia2、秀丽隐杆线虫CYK-1、裂殖酵母Cdc12或Fus1或酿酒酵母Bni1的FH1FH2构建体介导的肌动蛋白组装；在25μM时分解裂殖酵母中formin依赖性肌动蛋白索和收缩环；对NIH3T3成纤维细胞有细胞毒性(IC50=28μM)；在10μM时分别增加和减少具有细和粗F-肌动蛋白束的NIH3T3细胞的百分比。An FH2 domain inhibitor; inhibits assembly of profilin-actin mediated by mouse formin mDia1(FH1FH2) (IC50 = ~15 μM); inhibits actin assembly mediated by FH1FH2 constructs of mDia2, C. elegans CYK-1, S. pombe Cdc12 or Fus1, or S. cerevisiae Bni1; disassembles formin-dependent actin cables and contractile rings in fission yeast at 25 μM; cytotoxic to NIH3T3 fibroblasts (IC50 = 28 μM); increases and decreases the percentage of NIH3T3 cells with thin and thick F-actin bundles, respectively, at 10 μM.分子式C15H9BrN2O3S分子量377.2O=C1NC(N(C2=CC(Br)=CC=C2)C(/C1=C/C3=CC=CO3)=O)=S