Niacin-13C6

Animal Models of Niacin-Nicotinamide Deficiency

The human disease caused by niacin (vitamin B3 ) deficiency is pellagra, a disease that at one time filled insane asylums all over the world before the function of niacin was discovered. The recognition of pellagra as an endemic disease

Investigation of the Possible Role of TRP Channels in Schizophrenia

, are less sensitive to pain than normal subjects, and exhibit reduced niacin flare responses suggested that TRPV1 channels, and possibly also other temperature-sensitive TRPs that are co-expressed with TRPV1 on sensory neurons, might be linked with schizophrenia

Nat Metab：李贵登等团队合作发现肿瘤内酸度维持 T 细胞干性影响肿瘤免疫治疗

录组学、代谢组学以及同位素（13C6-葡萄糖，13C16-棕榈酸）示踪技术发现，长期胞外酸处理能够抑制 mTOR 信号通路及糖酵解途径，促进 T 细胞内的脂肪酸氧化（FAO），增强线粒体适应性, 从而维持「干性样」T 细胞的代谢表征。进一步深入分析以及通过 13C5-甲硫氨酸代谢流实验，作者们发现胞外酸度的升高显著抑制了 T 细胞内的甲硫氨酸摄入及一碳代谢（甲硫氨酸循环）。 机制上，一方面，胞外酸处理通过抑制 MYC 的表达，降低 T 细胞表面甲硫氨酸转运体（SLC7A5）的表达，进而削弱 T 细胞对胞外