Cecropin A (trifluoroacetate s

一种抗菌肽；在5µM浓度下诱导白色念珠菌细胞凋亡；对大肠杆菌菌株CFT073有效（MIC=100µg/ml）；提高CFT073感染的G.mellonella幼虫的存活率；降低肠道菌群拟杆菌科和肠杆菌科的富集，提高肠道乳酸杆菌的水平，同时提高DSS诱发的IBD小鼠模型的存活率并减少体重减轻。An antimicrobial peptide; induces apoptosis in C. albicans at 5 µM; active against the E. coli strain CFT073 (MIC = 100 µg/ml); increases survival of CFT073-infected G. mellonella larvae; decreases enrichment of the gut microflora Bacteroidaceae and Enterobacteriaceae and increases gut levels of Lactobacillus, as well as increases survival and decreases body weight loss in a mouse model of DSS-induced IBD.分子式C184H313N53O46 • XCF3COOH分子量4003.8OC(C(F)(F)F)=O.[H]NCCCC[C@H](NC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CCCCN[H])N[H])=O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN[H])C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(NCC(N[C@@](C(N[C@@](C(N[C@@H](CCCCN[H])C(N[C@H](C(NCC(N3CCC[C@H]3C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@]([H])([C@@H](C)O)C(N[C@@H](CCC(N)=O)C(N[C@@](C(N[C@H](C(N[C@@H](CCCCN[H])C(N)=O)=O)C)=O)([H])[C@H](CC)C)=O)=O)=O)C)=O)=O)=O)=O)=O)C)=O)=O)C)=O)=O)=O)C)=O)=O)([H])[C@H](CC)C)=O)([H])[C@H](CC)C)=O)=O)=O)=O)([H])[C@H](CC)C)=O)=O)=O)=O)=O)=O)=O)([H])[C@H](CC)C)=O)=O)=O)CC4=CC=CC=C4)=O)CC(C)C)=O