Miltirone

一种丹参酮（Tanshinone）化合物；在0.02%的浓度下可保护猪油免受热氧化；是苯二氮䓬受体的部分激动剂（IC50=0.3µM）；抑制CES2（Ki=0.04µM），以及SARS-CoV Mpro和PLpro（IC50分别为21.1µM和30µM）；对HCT116结肠癌细胞具有细胞毒性（IC50=4.27µM），并在相同细胞中诱导线粒体功能障碍和活性氧（ROS）产生；在小鼠中，以10-60mg/kg的剂量增加四板测试中的惩罚性穿越次数，表明其具有镇静活性。A tanshinone; protects lard from thermal oxidation at 0.02%; a partial agonist of the benzodiazepine receptor (IC50 = 0.3 µM); inhibits CES2 (Ki = 0.04 µM) as well as SARS-CoV Mpro and PLpro (IC50s = 21.1 and 30 µM, respectively); cytotoxic to HCT116 colon cancer cells (IC50 = 4.27 µM) and induces mitochondrial dysfunction and ROS production in the same cells; increases the number of punished crossings in the four-plate test, indicating tranquilizing activity, in mice at 10-60 mg/kg.分子式C19H22O2分子量282.4O=C1C(C(C(C)C)=CC2=C1C(CCCC3(C)C)=C3C=C2)=O