DPPE (fumarate)

AEBS配体（大鼠肝微粒体中的Ki=55.6nM）；10µM时对AEBS的选择性优于雌激素受体；对S10和MCF-7细胞有细胞毒性（IC50=7.5和12µM）；抑制分离的大鼠肥大细胞中抗原诱导的组胺释放（IC50=65-85µM）；减小未成熟卵巢切除大鼠的子宫大小；4mg/kg时保护小鼠骨髓祖细胞免受阿霉素诱导的细胞毒性。An AEBS ligand (Ki = 55.6 nM in rat liver microsomes); selective for the AEBS over the estrogen receptor at 10 µM; cytotoxic to S10 and MCF-7 cells (IC50s = 7.5 and 12 µM); inhibits antigen-induced histamine release in isolated rat mast cells (IC50 = 65-85 µM); decreases uterine size in immature oophorectomized rats; protects bone marrow progenitor cells from doxorubicin-induced cytotoxicity in mice at 4 mg/kg.分子式C19H25NO • C4H4O4分子量399.5O=C(C=CC(O)=O)O.CCN(CC)CCOC1=CC=C(CC2=CC=CC=C2)C=C1