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- Cayman
- 36001-1 mg
- 2025年07月20日
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一种NSAID；浓度为100µM时，可抑制A23187刺激的小鼠腹膜巨噬细胞中PGE2和LTC4的产生；浓度为25和50µg/ml时，可抑制血清诱导的大鼠腹膜白细胞趋化性；浓度为10µM时，可诱导人红细胞溶血，并以光依赖性方式诱导大鼠腹膜肥大细胞组胺释放；可减轻大鼠角叉菜胶诱发的爪水肿和酵母诱发的发热，以及小鼠乙酸诱发的翻滚。An NSAID; inhibits PGE2 and LTC4 production in A23187-stimulated isolated mouse peritoneal macrophages at 100 µM; inhibits serum-induced chemotaxis of isolated rat peritoneal leukocytes at 25 and 50 µg/ml; induces hemolysis in isolated human erythrocytes and histamine release in isolated rat peritoneal mast cells in a light-dependent manner at 10 µM; reduces carrageenan-induced paw edema and yeast-induced fever in rats and acetic acid-induced writhing in mice.分子式C16H12ClNO3分子量301.7O=C(C(C)C1=CC=C2OC(C3=CC=C(Cl)C=C3)=NC2=C1)O
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文献和实验相关实验
In Vitro Screening Assay of the Reactivity of Acyl Glucuronides
, benoxaprofen, ibufenac). The early identification of such reactivity for future development candidates would permit one to select equipotent products with less reactivity. The methodology to be followed in setting up an in vitro screening model of acyl
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Benoxaprofen
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