IM-156 (acetate)

线粒体复合物I抑制剂(IC50=2.2µM)和AMPKα激活剂；降低Eµ-Myc小鼠淋巴瘤细胞中的OCR(IC50=3.3µM)并减少线粒体ATP产生；在10、30和50µM时增加大鼠原代腹膜间皮细胞中的AMPKα活性；在1mg/kg时保护大鼠免受洗必泰诱发的腹膜纤维化；减缓AT-84鼠口腔癌模型中的肿瘤生长；减缓小鼠与年龄相关的新物体识别、空间工作和情境记忆的衰退。A mitochondrial complex I inhibitor (IC50 = 2.2 µM) and an AMPKα activator; reduces OCR (IC50 = 3.3 µM) and decreases mitochondrial ATP production in Eµ-Myc mouse lymphoma cells; increases AMPKα activity in primary rat peritoneal mesothelial cells at 10, 30, and 50 µM; protects against chlorhexidine-induced peritoneal fibrosis in rats at 1 mg/kg; reduces tumor growth in an AT-84 murine oral cancer model; decreases age-related decline in novel object recognition, spatial working, and contextual memory in mice.分子式C13H16F3N5O • XC2H4O2分子量315.3FC(F)(OC1=CC=C(NC(NC(N2CCCC2)=N)=N)C=C1)F.CC(O)=O