Turkesterone (hydrate)

一种植物蜕皮类固醇；与蜕皮类固醇受体结合（对C.tentans受体的KD=0.491µM）并诱导G.mellonella、S.bullata和D.vulpinus末龄幼虫化蛹（ED50s分别为10、0.03和0.2µg/幼虫）；在无细胞测定中清除DPPH自由基（IC50=140.92µg/ml），对HeLa宫颈癌、HepG2肝癌和MCF-7乳腺癌细胞有细胞毒性（IC50s分别为75.2、63.01和105.2µg/ml）；在10mg/kg剂量下，降低链脲佐菌素诱发的糖尿病大鼠的血清葡萄糖水平，并增加血清胰岛素和C肽水平；预防小鼠因束缚应激引起的胃溃疡。A phytoecdysteroid; binds to the ecdysteroid receptor (KD = 0.491 µM for the C. tentans receptor) and induces pupariation in G. mellonella, S. bullata, and D. vulpinus last instar larvae (ED50s = 10, 0.03, and 0.2 µg/larvae, respectively); scavenges DPPH radicals in a cell-free assay (IC50 = 140.92 µg/ml) and is cytotoxic to HeLa cervical, HepG2 hepatic, and MCF-7 breast cancer cells (IC50s = 75.2, 63.01, and 105.2 µg/ml, respectively); decreases serum glucose levels and increases serum insulin and C-peptide levels in alloxan-induced diabetic rats at 10 mg/kg; prevents immobilization stress-induced stomach ulcers in mice.分子式C27H44O8 • XH2O分子量496.6O[C@]12C([C@@]([C@@H](C[C@@]1([C@]([C@@](C)(O)[C@H](O)CCC(C)(O)C)([H])CC2)C)O)([H])[C@@]3([C@@]4([H])C[C@H]([C@H](C3)O)O)C)=CC4=O.O