Escin Ib

一种具有多种生物活性的三萜皂苷；抑制HIV-1蛋白酶(IC50=50µM)；50-200mg/kg剂量下可抑制角叉菜胶诱发的大鼠爪水肿和化合物48/80诱发的小鼠抓挠行为；抑制大鼠的乙醇吸收并提高葡萄糖耐受性；10-50mg/kg剂量下可减小乙醇诱发的大鼠胃溃疡模型中的粘膜病变大小和严重程度。A triterpene saponin with diverse biological activities; inhibits HIV-1 protease (IC50 = 50 µM); inhibits carrageenan-induced paw edema in rats and compound 48/80-induced scratching behavior in mice from 50-200 mg/kg; inhibits ethanol absorption and increases glucose tolerance in rats; decreases mucosal lesion size and severity in a rat model of ethanol-induced gastric ulcers from 10-50 mg/kg.分子式C55H86O24分子量1131.3OC[C@]12[C@](CC(C)([C@H]([C@@H]2OC(C)=O)OC(/C(C)=C\C)=O)C)([H])C3=CC[C@@]([C@@]4([C@@]([C@](C)([C@H](CC4)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)C(O)=O)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO)O)O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)CO)CO)([H])CC8)C)([H])[C@]8(C)[C@@]3(C[C@H]1O)C