Aromadendrin

一种具有多种生物活性的黄酮；在无细胞测定中，可清除DPPH自由基(IC50=2.21µM)并抑制AChE(IC50=35.43µM)，但不抑制BChE和BACE1(IC50s=>200µM)；抑制BT474、ChaGo-K-1、HepG2、KATO-III和SW620细胞的生长(IC50s分别为11.66、12.32、13.67、39.79和41.11µM)；阻止抗CD3和抗CD28刺激的T细胞中产生细胞因子；减轻小鼠caerulin和LPS诱发的重度急性胰腺炎模型中的胰腺损伤。A flavone with diverse biological activities; scavenges DPPH radicals (IC50 = 2.21 µM) and inhibits AChE (IC50 = 35.43 µM), but not BChE and BACE1 (IC50s = >200 µM), in cell-free assays; inhibits the growth of BT474, ChaGo-K-1, HepG2, KATO-III, and SW620 cells (IC50s = 11.66, 12.32, 13.67, 39.79, and 41.11 µM, respectively); prevents cytokine production in anti-CD3 and anti-CD28-stimulated T cells; reduces pancreatic damage in a mouse model of caerulin and LPS-induced severe acute pancreatitis.分子式C15H12O6分子量288.3OC1=C2C(O[C@H]([C@@H](C2=O)O)C3=CC=C(O)C=C3)=CC(O)=C1