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- 文献和实验
- 技术资料
- 保存条件：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Deferoxamine Mesylate
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
138-14-7
- 规格：
50mg
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Deferoxamine-loaded gelatin methacryloyl hydrogel endue 3D-printed PGCL-hydroxyapatite scaffold with angiogenesis, anti-oxidative and immunoregulatory capacities for facilitating bone healing
成员:Yanlin Zhu, Zuosen Shi, Yuxuan Pang, Yanmin Zhou
论文因子:7.7 发表期刊:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES pmid:39756750
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Porous hydroxyapatite scaffold orchestrated with bioactive coatings for rapid bone repair
成员:Yingzheng Zhao, Hangbo Chen, Kunjie Ran, Yingying Zhang, Hanxiao Pan, Jianxun Shangguan, Mengqi Tong, Jiaojiao Yang, Qing Yao, Helin Xu
论文因子:0 发表期刊:Biomaterials Advances pmid:36434928
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Hexabromocyclododecane (HBCD) exposure induced premature testicular aging via NCOA4/Fe2+/ROS mediation
成员:Deyi Wu, Yuebing Kong, Ruoting Zhang, Jiawen Li, Guoxia Wang, Meng Zhang, Hainan Lan
论文因子:4.8 发表期刊:INTERNATIONAL IMMUNOPHARMACOLOGY pmid:39067400
| 基本信息 | |
| CAS | No.138-14-7 |
| 中文名称 | 甲磺酸去铁胺 |
| 英文名称 | Deferoxamine Mesylate |
| 别名 | 甲磺酸去铁胺;去铁胺甲磺酸盐;DEFEROX胺甲磺酸盐;甲磺酸除铁灵;去铁胺甲磺酸酯; |
| 分子式 | C26H52N6O11S |
| 分子量 | 656.79 |
| 溶解性 | Soluble in Water ≥20mg/mL |
| 纯度 | ≥92% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 205-314-3 |
| MDL | MFCD00058605 |
| SMILES | O=C(N(CCCCCN)O)CCC(NCCCCCN(C(CCC(NCCCCCN(C(C)=O)O)=O)=O)O)=O.CS(=O)(O)=O |
| InChIKey | IDDIJAWJANBQLJ-UHFFFAOYSA-N |
| InChI | InChI=1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4) |
| PubChem CID | 62881 |
| 靶点 | Amyloid-β;Ferroptosis |
| 通路 | Neuronal Signaling |
| 背景说明 | Deferoxamine mesylate是Deferoxamine的甲磺酸盐,是一种铁螯合剂。Deferoxamine 是一种铁死亡的抑制剂。Deferoxamine 可降低 beta-amyloid (Aβ) 的沉积并诱导自噬。 |
| 生物活性 | Deferoxamine mesylate (Ba 33112， Desferrioxamine B， DFOM， NSC 644468)是Deferoxamine的甲磺酸盐，它可形成铁络合物并用作螯合剂。Deferoxamine 是一种铁死亡的抑制剂，可在体外低氧和高血糖状态下稳定 HIF-1α 的表达并改善HIF-1α的活性。Deferoxamine 可降低 beta-amyloid (Aβ) 的沉积并诱导自噬。[1-3] |
| In Vitro | Deferoxamine mesylate，the iron chelator and ferroptosis inhibitor，rescues neutrophil death induced by systemic lupus erythematosus(SLE)serum，suggesting that ferroptosis may be the main form of neutrophil death in SLE.[3] |
| 动物实验 | A rat model of Deferoxamine at thoracic 10 segment was established using a modified Allen's method. Ninety 8-week-old female Wistar rats were used. Rats in the Deferoxamine group were intraperitoneally injected with 100 mg/kg Deferoxamine 30 minutes before injury. Simultaneously，the Sham and Deferoxamine groups served as controls. Drug administration was conducted for 7 consecutive days.[2] |
| 数据来源文献 | [1] Chuang Guo， et al. Front Aging Neurosci . 2015 Jun 2;7:104. [2] Xue Yao， et al. Neural Regen Res . 2019 Mar;14(3):532-541. [3] Li P， et al. Nat Immunol. 2021 Sep;22(9):1107-1117. |
| 单位 | 瓶 |
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文献和实验【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Deferoxamine-loaded gelatin methacryloyl hydrogel endue 3D-printed PGCL-hydroxyapatite scaffold with angiogenesis, anti-oxidative and immunoregulatory capacities for facilitating bone healing
成员:Yanlin Zhu, Zuosen Shi, Yuxuan Pang, Yanmin Zhou
论文因子:7.7 发表期刊:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES pmid:39756750
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Porous hydroxyapatite scaffold orchestrated with bioactive coatings for rapid bone repair
成员:Yingzheng Zhao, Hangbo Chen, Kunjie Ran, Yingying Zhang, Hanxiao Pan, Jianxun Shangguan, Mengqi Tong, Jiaojiao Yang, Qing Yao, Helin Xu
论文因子:0 发表期刊:Biomaterials Advances pmid:36434928
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Hexabromocyclododecane (HBCD) exposure induced premature testicular aging via NCOA4/Fe2+/ROS mediation
成员:Deyi Wu, Yuebing Kong, Ruoting Zhang, Jiawen Li, Guoxia Wang, Meng Zhang, Hainan Lan
论文因子:4.8 发表期刊:INTERNATIONAL IMMUNOPHARMACOLOGY pmid:39067400
, we may find much more references regarding this issue. http://books.google.com/books?id=3mgPzNFjcWAC&pg=PA51&lpg=PA51&dq=gsk+tyrosine+phosphorylation+and+activity&source=bl&ots=x5ueTldpez&sig=CqRFJleXtEBn9OfelhODPAc28xs&hl=en&ei=KerNSu-XGcem8Abm-qmABA&sa=X&oi=book_result&ct
)及磷脂过氧化氢谷胱甘肽氧化酶(PHGSH�x)的组成成分。GSH�x中每克分子酶四聚体含有4克原子硒，硒半胱氨酸的硒醇是酶的催化中心。该酶在人体内起抗氧化作用，能催化GSH与胞液中的过氧化物反应，防止过氧化物对机体的损伤。GSH�x活力下降，线粒体不可逆地失去容积控制和收缩能力并最后破裂。缺硒所致肝坏死可能是过氧化物代谢受损的结果。PHGSH�x与GSH�x不同，它存在于肝和心肌细胞线粒体内膜间隙中，作用是抗氧化、维持线粒体的完整，避免脂质过氧化物伤害。此外，I型碘甲腺原氨酸5′－脱碘酶(5′�ID
of complex and protein alone with the naked eye or a light microscope, crystals of covalently Cy5?labeled DNA can be directly used for X?ray diffraction data collection. Curr. Protoc. Nucleic Acid Chem. 46:7.15.1?7.15.8. © 2011 by John Wiley & Sons
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