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- 文献和实验
- 技术资料
- 保存条件：
Store at -20℃，6 months.
- 保质期：
Store at -20℃，6 months.
- 英文名：
Artesunate(10mM in DMSO，Sterile)
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- CAS号：
88495-63-0
- 规格：
1ml/1.5ml/0.5ml/0.3ml/0.1ml
| 规格： | 1ml | 产品价格： | ¥590.00 |
|---|---|---|---|
| 规格： | 1.5ml | 产品价格： | ¥767.00 |
| 规格： | 0.5ml | 产品价格： | ¥472.00 |
| 规格： | 0.3ml | 产品价格： | ¥354.00 |
| 规格： | 0.1ml | 产品价格： | ¥236.00 |
| CAS | 88495-63-0 |
| 中文名称 | 青蒿琥酯(10mM in DMSO，无菌） |
| 英文名称 | Artesunate(10mM in DMSO，Sterile) |
| 分子式 | C19H28O8 |
| 分子量 | 384.42 |
| 规格 | 1ml ; 1.5ml ; 0.5ml ; 0.3ml ; 0.1ml |
| 溶解性 | 请根据自己的实验要求使用。 |
| 外观(性状) | 无菌溶液 |
| 储存条件 | Store at -20℃，6 months. |
| 运输条件 | 冷冻运输 |
| EC | 618-170-5 |
| MDL | MFCD00866204 |
| SMILES | C[C@@H]1CC[C@H]2[C@H]([C@@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)OC(=O)CCC(=O)O)C |
| InChIKey | FIHJKUPKCHIPAT-AHIGJZGOSA-N |
| InChI | InChI=1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3，25-17)26-27-19/h10-13，16-17H，4-9H2，1-3H3，(H，20，21)/t10-，11-，12+，13+，16-，17-，18-，19-/m1/s1 |
| PubChem CID | 6917864 |
| 靶点 | STAT3;exported protein 1 (EXP1) |
| 通路 | JAK/STAT Signaling |
| 背景说明 | Artesunate是 STAT-3 和EXP1 的抑制剂。 |
| 生物活性 | Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).[1-3] |
| In Vitro | Artesunate is an inhibitor of both STAT-3[1] and exported protein 1 (EXP1)[2]. Artesunate treatment for 24 h causes a significant increase in the levels of reactive oxygen species (ROS) in a dose-dependent manner in both cell lines. Moreover， Western blotting shows that the levels ofγ-H2AX are significantly elevated when cancer cells are treated with Artesunate in the higher dose range for 24 h. Artesunate also shows a time-dependent effect on the level of RAD51 in A2780 and HO8910 cells. In two types of non-malignant cells， normal human fibroblasts and immortalized epithelial cells， FTE-187， the level of RAD51 is not altered by Artesunate. In A2780 cells， the level of RAD51 mRNA is indeed decreased by the addition of Artesunate， in a dose-dependent manner. Correspondingly， the promoter activity of RAD51 is significantly inhibited by Artesunate. In contrast， the RAD51 mRNA level in H8910 cells is not affected by Artesunate[3]. |
| In Vivo | Tumor growth is significantly reduced in the group receiving combined treatment of Artesunate and cisplatin (P[3]. |
| 细胞实验 | A2780 and HO8910 cells are cultured in RPMI 1640， Normal human fibroblasts (NHF) in DMEM， and FTE-187 in M199， supplemented with 10% fetal bovine serum， 100 units/mL penicillin， and 100 mg/mL streptomycin. All the cells are incubated in a humidified atmosphere of 95% air and 5% CO2. Artesunate is applied to the cultured cells at the concentration of 0， 5， 10， 25， or 50 μg/mL for various periods. The reactive oxygen species (ROS) production following Artesunate treatment is determined. Briefly， cells are loaded with 5 μM of CM-H2DCFDA and incubated at 37°C for 20 min after treatment with Artesunate. Cells are resuspended using preserving fluid and analyzed with a FACSCanto II. The peak excitation wavelength for oxidized CM-H2DCFDA is 490 nm and emission is 530 nm[3]. |
| 动物实验 | Four to six weeks old female athymic nude mice (BALB/c， nu/nu) are used. A2780 and HO8910 cells are harvested and resuspended in 0.1 ml of PBS， 5×106 cells/0.2 mL are injected subcutaneously into the left inguinal area of the mice. Two weeks later， mice bearing tumors (~70 mm3 for A2780 and HO8910) are randomly divided into 4 groups. Artesunate is administered daily via i.p. injection at doses of 50 mg/kg alone for 16 days. The tumor growth is monitored every other day. Tumor volume is determined by the formula 1/2a×b2 where a is the long diameter (mm) and b is the short diameter (mm)[3]. |
| 激酶实验 | After treatment with Artesunate for 24 h， cells are harvested and lysed in 1×cell lysis buffer. Total proteins of 15 to 25 μg are separated by SDS-PAGE and transferred to polyvinylidenedifluoride (PVDF) membranes. Membranes are blocked with 5% non-fat milk for 1 to 2 h at room temperature and then probed with primary antibodies and incubated at 4°C overnight. After extensive washing with TBS-T， membranes are incubated with appropriate HRP-conjugated secondary antibody for 1 h at room temperature， and then are detected by Western ECL-enhanced luminol reagent [3]. |
| 数据来源文献 | [1]. Ilamathi M， et al. Artesunate as an Anti-Cancer Agent Targets Stat-3 and Favorably Suppresses Hepatocellular Carcinoma. Curr Top Med Chem. 2016;16(22):2453-63. [2]. Lisewski AM， et al. Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate. Cell. 2014 Aug 14;158(4):916-928. [3]. Wang B， et al. Artesunate sensitizes ovarian cancer cells to cisplatin by downregulating RAD51. Cancer Biol Ther. 2015;16(10):1548-56. |
| 单位 | 瓶 |
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文献和实验相关实验
商品化试剂和培养基均经过严格的质量控制以保证其无菌，但它们在操作过程中可能被污染。请遵循以下指导原则进行无菌操作，避免污染。请始终使用适当的灭菌方法（如高压灭菌器、除菌过滤器）对实验室中配制的任何试剂、培养基或溶液进行灭菌。 无菌操作 请始终用 70% 乙醇擦拭双手和工作区。 将容器、培养瓶、培养板和培养皿放入细胞培养通风橱之前，先用 70% 乙醇擦拭其外部。 不要直接从试剂瓶或培养瓶中倾倒培养基和试剂。 使用无菌玻璃或一次性塑料移液管和移液器操作液体时，每只移液管只能使用一次，以避免
培养基经高压灭菌后，用经过灭菌的工具（如接种针和吸管等）在无菌条件下接种含菌材料（如样品、菌苔或菌悬液等）于培养基上，这个过程叫做无菌接种操作。在实验室检验中的各种接种必须是无菌操作。 实验台面不论是什么材料，一律要求光滑、水平。光滑是便于用消毒剂擦洗；水平是倒琼脂培养基时利于培养皿内平板的厚度保持一致。在实验台上方，空气流动应缓慢，杂菌应尽量减少，其周围杂菌也应越少越好。为此，必须清扫室内，关闭实验室的门窗，并用消毒剂进行空气消毒处理，尽可能地减少杂菌的数量
工业级-DMSO用途： 主要用于无水有机化学合成反应和医药及中间体合成反应溶剂，使用该溶剂能提高化学反应速度，提高反应物的了收率，缩短反应时间，使合成反应变得更加顺利。 试剂级-DMSO用途: DMSO用作液体层析溶剂，同时用作测试物质紫外消光值上时用作参照物，存在于液体形态。 (责任编辑：大汉昆仑王)
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青蒿琥酯(10mM in DMSO，无菌)
¥236 - 767
