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- 文献和实验
- 技术资料
- 保存条件：
Store at -20℃，6 months.
- 保质期：
Store at -20℃，6 months.
- 英文名：
β-n-Oxalylamino-l-alanine(10mM in DMSO，Sterile)
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- CAS号：
5302-45-4
- 规格：
1ml
| CAS | 5302-45-4 |
| 中文名称 | 三七素(10mM in DMSO，无菌） |
| 英文名称 | β-n-Oxalylamino-l-alanine(10mM in DMSO，Sterile) |
| 分子式 | C5H8N2O5 |
| 分子量 | 176.13 |
| 规格 | 1ml |
| 溶解性 | 请根据自己的实验要求使用。 |
| 外观(性状) | 无菌溶液 |
| 储存条件 | Store at -20℃，6 months. |
| 运输条件 | 冷冻运输 |
| SMILES | C([C@@H](C(=O)O)N)NC(=O)C(=O)O |
| InChIKey | NEEQFPMRODQIKX-REOHCLBHSA-N |
| InChI | InChI=1S/C5H8N2O5/c6-2(4(9)10)1-7-3(8)5(11)12/h2H，1，6H2，(H，7，8)(H，9，10)(H，11，12)/t2-/m0/s1 |
| PubChem CID | 440259 |
| 靶点 | HIF/HIF Prolyl-Hydroxylase |
| 通路 | HIF |
| 背景说明 | β-n-Oxalylamino-l-alanine是一种HIF-prolyl hydroxylase-2 (PHD-2) 抑制剂。 |
| 生物活性 | Dencichin is a non-protein amino acid originally extracted from Panax notoginseng， and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity.[1-2] |
| In Vitro | Dencichin (β-ODAP， 10 μM， 50 μM， 100 μM and 200 μM) increases HRE expression by 1.3±0.09， 2.5±0.07， 4.2±0.15 and 1.3±0.07 fold respectively compared to control. Dencichin has intermolecular interactions with PHD-2[1]. Dencichin (10 μM， 100 μM， 1 mM) significantly inhibits cell proliferation and extracellular matrix (ECM) proteins accumulation of HBZY-1 cells， and reduces the secretion of collagen I (Col I)， collagen IV (Col IV)， and fibronectin (FN)[2]. |
| In Vivo | Dencichin improves metabolism disorder in diabetic nephropathy (DN) secondary to type II diabetes mellitus (DM) model. Dencichin (80， 160 mg/kg/day， p.o.) significantly prevents the up-regulation of TCH， TG， LDL， and HbAlc and the down-regulation of HDL in DN rats induced by STZ injection. Dencichin also attenuates renal injury induced in the DN secondary to type II DM model. Dencichin alleviates pancreas damage in the STZ-induced DN model. Dencichin regulates protein expression in the TGF-β/Smad signalling pathway in STZ-induced DN models[2]. |
| 细胞实验 | Cells are cultured in 6-well plates with glucose (LG) or high glucose control (HG) and then treated with valsartan (1.0 × 10-3 M) or Dencichin (1.0 × 10-5 M， 1.0 × 10-4 M and 1.0 × 10-3 M) for 24 h before analysing the activation of FN， Col I， and Col IV expression by ELISA and analysing MMP-9 and TIMP-1 expression by immunofluorescence. Each experiment is repeated at least three times throughout the study[2]. |
| 动物实验 | Male SD rats weighted approximately 200 ± 20 g (eight weeks old) are kept at 23 ± 2°C. The rats are randomLy allotted into two groups: normal group (n = 16) and diabetic nephropathy (DN) group (n = 60). The normal rats fed with normal diet and vehicle fall into the normal control group (NC， n = 8) and the normal rats fed with normal diet and Dencichin fall into the Dencichin control group (De C， n = 8). The rats in the diabetic group are fed the high-sugar-high-fat diet (composition: Common breeding material 54.6%， lard oil 16.9%， sucrose 14%， casein 10.2%， gunk 2.1%， maltodextrin 2.2%). Five weeks later， DN is induced by administering of 40 mg/kg STZ though intraperitoneal injection， and the normal rats are treated with vehiclecitrate buffer (0.1 M， pH 4.2). Next， the DN rats (n = 32) are assigned into four groups and oral administered with metformin hydrochloride (a positive control) at 80 mg/kg/day， (DN+Met， n = 8)， which is dissolve into distilled water to make a 2 mg/mL solution before use; vehicle control for the DN control group (DN， n = 8)， or Dencichin. The Dencichin group is divided into a high Dencichin group (160 mg/kg/day; DN+De H， n = 8) and a low Dencichin group (80 mg/kg/day; DN+De L， n = 8)， which are dissolved into distilled water to make a 5 mg/mL and 2.5 mg/mL solution before use and oral administered at the dosage once per day. Blood glucose is measured each month. 8 w after administering with Dencichin， the rats are killed[2]. |
| 数据来源文献 | [1]. Eslavath RK， et al. β-N-oxalyl-L-α， β- diaminopropionic acid induces HRE expression by inhibiting HIF-prolyl hydroxylase-2 in normoxic conditions. Eur J Pharmacol. 2016 Nov 15;791:405-411. [2]. Jie L， et al. Dencichine ameliorates kidney injury in induced type II diabetic nephropathy via the TGF-β/Smad signalling pathway. Eur J Pharmacol. 2017 Oct 5;812:196-205. |
| 单位 | 瓶 |
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文献和实验相关实验
商品化试剂和培养基均经过严格的质量控制以保证其无菌，但它们在操作过程中可能被污染。请遵循以下指导原则进行无菌操作，避免污染。请始终使用适当的灭菌方法（如高压灭菌器、除菌过滤器）对实验室中配制的任何试剂、培养基或溶液进行灭菌。 无菌操作 请始终用 70% 乙醇擦拭双手和工作区。 将容器、培养瓶、培养板和培养皿放入细胞培养通风橱之前，先用 70% 乙醇擦拭其外部。 不要直接从试剂瓶或培养瓶中倾倒培养基和试剂。 使用无菌玻璃或一次性塑料移液管和移液器操作液体时，每只移液管只能使用一次，以避免
培养基经高压灭菌后，用经过灭菌的工具（如接种针和吸管等）在无菌条件下接种含菌材料（如样品、菌苔或菌悬液等）于培养基上，这个过程叫做无菌接种操作。在实验室检验中的各种接种必须是无菌操作。 实验台面不论是什么材料，一律要求光滑、水平。光滑是便于用消毒剂擦洗；水平是倒琼脂培养基时利于培养皿内平板的厚度保持一致。在实验台上方，空气流动应缓慢，杂菌应尽量减少，其周围杂菌也应越少越好。为此，必须清扫室内，关闭实验室的门窗，并用消毒剂进行空气消毒处理，尽可能地减少杂菌的数量
工业级-DMSO用途： 主要用于无水有机化学合成反应和医药及中间体合成反应溶剂，使用该溶剂能提高化学反应速度，提高反应物的了收率，缩短反应时间，使合成反应变得更加顺利。 试剂级-DMSO用途: DMSO用作液体层析溶剂，同时用作测试物质紫外消光值上时用作参照物，存在于液体形态。 (责任编辑：大汉昆仑王)
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三七素(10mM in DMSO，无菌)
¥970
