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文献和实验指能使药物及其制剂稳定性增强的药物。稳定剂的种类很多,增强药物化学稳定性的稳定剂包括延缓水解的药物或溶媒、抗氧化作用的抗氧剂、金属离子鳌合剂等;增强药物物理稳定性的稳定剂,如混悬剂中延缓沉降的助悬剂、使酊剂中沉淀溶解的增溶剂等;增强药物制剂生物稳定性的稳定剂,如防腐剂等。
Xenopus Cell-Free Extracts to Study DNA Damage Checkpoints
Surveillance mechanisms monitoring genomic integrity operate through signal transduction pathways called checkpoints. Checkpoints are essential to delay cell cycle progression in response to deoxyribonucleic acid (DNA) damage
Xenopus Cell-Free Extracts to Study the DNA Damage Response
Cell-free systems derived from Xenopus eggs represent a powerful tool, intermediate between in vitro and in vivo model systems. Here, we describe protocols to prepare cell-free extracts recapitulating several aspects of the DNA damage response
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