1,3,5-trimethoxybenzene (alias

SNAr-Based Cycloetherification Methodology: Application in the Synthesis of Heterodectic Macrocyclic Peptides with Endo Aryl-Aryl and Aryl-Alkyl Ether

The endo aryl-aryl and aryl-alkyl ether bonds exist in a number of biologically important macrocyclic natural products, such as vancomycin family glycopeptide antibiotics ( 1 – 3 ), antitumor series RA I-XIV ( 4 ), K-13 ( 5 ), OF4949

Enantioseparations of Primary Amino Compounds by High-Performance Liquid Chromatography Using Chiral Crown Ether-Based Chiral Stationary Phase

Liquid chromatographic resolution of racemic compounds containing a primary amino group has been known to be most successful when chiral crown ether-based chiral stationary phases (CSPs) are used. Among various crown ether

Synthesis of an Esterase-Sensitive Cyclic Prodrug of a Model Hexapeptide Having Enhanced Membrane Permeability and Enzymatic Stability Using a 3-(2-Hy

by taking advantage of a unique “trimethyl lock”-facilitated lactonization system (Fig. 1 ). Substituted phenol propionic acid derivatives such as 2 , upon unmasking of the hydroxyl group, undergo a facile spontaneous intramolecular cyclization to release