- ￥2260
- LSM Bio
- 进口
- PAab09997
- 2025年07月14日
- ELISA, WB, IHC
- E. coli - derived recombinant protein
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
cell division cycle 20 homolog
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
polyclonal
- 标记物：
Non-conjugated
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9BZJ3
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA, WB, IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
cell division cycle 20 homolog
- 抗体英文名：
Cdc20 antibody
- 抗体名：
Cdc20 antibody
- 规格：
100μl
Cdc20 antibody
Product Name Cdc20 antibody
Catalog No PAab09997
Packing 100ul
Form liquid
Alternative Name CDC20, CDC20A, p55CDC
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome(APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
Immunogen cell division cycle 20 homolog
Specificity Human
Tested Application ELISA, WB, IHC
Recommended dilution WB: 1:500-1:2000; IHC: 1:20-1:200
IHC use Immunohistochemistry of paraffin-embedded human colon cancer using PAab09997(CDC20 antibody) at dilution of 1:100
WB use
HeLa cells were subjected to SDS PAGE followed by western blot with PAab09997(CDC20 antibody) at dilution of 1:1000
Protein Information
Gene ID 991
Uniprot ID Q12834
Calculated MW 55 kDa
Research Area Cell Division and Proliferation, Metabolism
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文献和实验An In Vitro Assay for Cdc20-Dependent Mitotic Anaphase-Promoting Complex Activity from Budding Yeast
protein co-factor called Cdc20. In vitro Cdc20-dependent APC (APCCdc20 ) assays have been useful in the identification and validation of target substrates, and in the study of APC enzymology and regulation. Many aspects of the regulation of cell cycle
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera
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