- ￥2260
- LSM Bio
- 进口
- PAab09951
- 2025年07月15日
- ELISA, WB
- E. coli - derived recombinant protein
- Human, Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
advanced glycosylation end product-specific receptor
- 亚型：
IgG1
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
monoclonal
- 标记物：
Non-conjugated
- 适应物种：
Human, Rat
- 保质期：
6个月
- 抗原来源：
Mouse
- 目录编号：
Q9BZJ3
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA, WB
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
advanced glycosylation end product-specific receptor
- 抗体英文名：
AGER antibody
- 抗体名：
AGER antibody
- 规格：
100μl
AGER antibody
Product Name AGER antibody
Catalog No PAab09951
Packing 100ul
Form liquid
Alternative Name AGER, RAGE
Purification protein A+G purified
Purity 95% as determined by SDS-PAGE
Host Mouse
Isotype IgG1
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Mediates interactions of advanced glycosylation end products(AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling(By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide(ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase(MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
Immunogen advanced glycosylation end product-specific receptor
Specificity Human, Rat
Tested Application ELISA, WB
Recommended dilution WB: 1:1000-1:5000
IHC use
WB use
Rar lung tissue were subjected to SDS PAGE followed by western blot with PAab09951(AGER Antibody) at dilution of 1:2000
Protein Information
Gene ID 177
Uniprot ID Q15109
Calculated MW 43 kDa
Research Area Immunology, Signal Transduction, Developmental biology
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文献和实验Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera
General comments: Antibodies, like most proteins, do not like to be freeze-thawed. Avoid repetitive freezing of your solution. The best way to store your antibody is to keep a high protein concentration (>1 mg/ml), add some protease
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