- ￥2062
- LSM Bio
- 进口
- PAab00209
- 2025年07月15日
- ELISA,WB,IHC
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
advanced glycosylation end product-specific receptor
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9GZT9
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
AGER
- 抗体英文名：
anti-AGER antibody,AGER antibody
- 抗体名：
anti-AGER 抗体,AGER 抗体
- 规格：
100μg
AGER抗体| AGER antibody
货号 PAab00209
蛋白别名 AGER antibody, RAGE
蛋白介绍
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
产品描述
anti-AGER antibody is a Rabbit Polyclonal antibody againstAGER..
建议稀释比例
WB :1:200-1:2000;IHC:1:20-1:200
IHC
Immunohistochemistry of paraffin-embedded human renal cell carcinoma tissue slide using PAab00209( AGER Antibody) at dilution of 1:200
Western blot
mouse lung tissue were subjected to SDS PAGE followed by western blot with PAab00209( AGER Antibody) at dilution of 1:600(本抗体仅供体外科研用途，不可用于临床诊断!)
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文献和实验
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