- ￥2260
- LSM Bio
- 进口
- PAab098271
- 2025年07月14日
- ELISA, WB, IHC
- E. coli - derived recombinant protein
- Human, Mouse, Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Cytochrome c
- 亚型：
IgG2a
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
monoclonal
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse, Rat
- 保质期：
6个月
- 抗原来源：
Mouse
- 目录编号：
Q9BZJ3
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA, WB, IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
Cytochrome c
- 抗体英文名：
Cytochrome c antibody
- 抗体名：
Cytochrome c antibody
- 规格：
100μl
Cytochrome c antibody
Product Name Cytochrome c antibody
Catalog No PAab098271
Packing 100ul
Form liquid
Alternative Name CYC, CYCS, Cytochrome c, cytochrome c, somatic, HCS, THC4
Purification Protein A+G purification
Purity 95% as determined by SDS-PAGE
Host Mouse
Isotype IgG2a
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Cytochrome c is a 12-15 kDa electron transporting protein located in the inner mitochondrial membrane. Upon apoptotic stimulation, cytochrome c can be released from mitochondria into cytoplasm, resulting in caspase-3 activation and apoptosis. Measurement of cytochrome c release from the mitochondria is useful for detection of the onset of apoptosis in cells. In addition, cytochrome c can also leave cells and be detectable in extra-cellular medium of apoptotic cells and serum of cancer patients. The level of serum cytochrome c may serve as a prognostic maker during cancer therapy.
Immunogen Cytochrome c
Specificity Human, Mouse, Rat
Tested Application ELISA, WB, IHC
Recommended dilution WB: 1:5000-1:30000; IHC: 1:100-1:1000
IHC use Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using PAab098271( Cytochrome c Antibody) at dilution of 1:600
WB use
Hela cells were subjected to SDS PAGE followed by western blot with PAab098271(Cytochrome c antibody) at dilution of 1:20000
Protein Information
Gene ID 54205
Uniprot ID P99999
Calculated MW 150 kDa
Research Area Cardiovascular, Metabolism
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文献和实验广义的细胞色素 c是含有血红素 c的细胞色素之总称。通常是指主要存在于高等动植物、酵母、霉菌等线粒体中的细胞色素 c，起着传递电子的作用。为分子量约 1.3万的碱性蛋白质，还原型的吸收带为 550、 520、 415毫微米，氧化型为 407毫微米。α 因此很早便被研究，并获得结晶。不仅一级结构而且立体结构也已清楚（图 1）。其结构基本上是生物界共有的。由细胞色素 c氧化酶〔细胞色素（ a＋ a3 ）复合体〕氧化。在呼吸链中从细胞色素 c开始接受电子，各种还原酶都已清楚
Cytochrome c Stabilization and Immobilization in Aerogels
structurally intact within the gels during the necessary supercritical fluid processing. However, the heme protein cytochrome c (cyt. c ) forms self-organized superstructures around gold (or silver) nanoparticles in buffer that can be encapsulated within silica
Assessing Cytochrome-c Release from Mitochondria
In recent years substantial evidence has accumulated demonstrating a central regulatory role for mitochondria in cell death (1 ). More recently, mechanisms of cell death, through apoptosis, have been elucidated
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