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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
sterile alpha motif and leucine zipper containing kinase AZK
- 亚型:
IgG
- 形态:
liquid
- 保存条件:
负20摄氏度
- 克隆性:
Polyclonal antibody
- 标记物:
Non-conjugated
- 适应物种:
Human,Mouse ,Rat
- 保质期:
6个月
- 抗原来源:
Rabbit
- 目录编号:
O95498
- 级别:
纯化级别
- 库存:
50
- 供应商:
LSM bio
- 宿主:
E. coli - derived recombinant protein
- 应用范围:
ELISA,WB,IHC,IF
- 浓度:
≥95% as determined by SDS-PAGE
- 靶点:
sterile alpha motif and leucine zipper containing kinase AZK
- 抗体英文名:
anti-ZAK antibody,ZAK antibody
- 抗体名:
anti-ZAK 抗体,ZAK 抗体
- 规格:
100μl
ZAK抗体| ZAK antibody
货号 PAab09581
蛋白别名 AZK antibody, HCCS 4 antibody, MLK related kinase antibody, MLK7 antibody, mlklak antibody, MLT antibody, MLTK antibody, MRK antibody, ZAK
蛋白介绍
Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636). Isoform 1: Phosphorylates histone H3 at 'Ser-28' (PubMed:15684425). May have role in neoplastic cell transformation and cancer development (PubMed:15172994). Causes cell shrinkage and disruption of actin stress fibers (PubMed:11042189).
产品描述
anti-ZAK antibody is a Rabbit Polyclonal antibody againstZAK..
建议稀释比例
WB:1:500-1:5000;IHC:1:20-1:200;IF:1:10-1:100
IHC
Immunohistochemistry of paraffin-embedded human liver tissue slide using PAab09581( ZAK Antibody) at dilution of 1:50
Western blot
HepG2 cells were subjected to SDS PAGE followed by western blot with PAab09581(ZAK antibody) at dilution of 1:500(本抗体仅供体外科研用途,不可用于临床诊断!) "">
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文献和实验,后者是试验中使用的另一种MS药物。这表明,包含这四个snp的特征是特异性的共轴突反应,而不仅仅是MS进展或IFN-β反应的指标。snp是MBP、HLA-DQB2、UVRAG和ZAK(CDCA7)四个基因的组成部分。在人体的中枢神经系统中,神经的保护层,即髓鞘,有助于信号的快速传导,使细胞能够相互通信。在MS患者中,来自免疫系统的错误引导的T细胞攻击髓鞘,剥离髓鞘并随着时间的推移损伤神经。HLA-DQB2是一种能产生蛋白质的基因,这种蛋白质能使免疫系统识别并攻击髓鞘。通过模仿组成髓鞘的髓鞘碱性蛋白(MBP
三句话读懂一篇 CNS,胶原不仅能护肤还能护心,结构细胞也具有免疫功能,肥胖导致后代特定肝癌易感...
的小鼠心脏受损后会形成更大的疤痕并影响心脏功能。看来胶原蛋白不仅能护肤,还能护心。(Cell)9. Nature 和 Cell 同时关注,核糖体在细胞应激过程中的作用 当细胞受到外界环境或自身变化刺激时会产生应激反应,在应激反应中许多基因表达发生变化来度过这一时期,其中,核糖体作为 mRNA 翻译的场所在细胞应激反应中至关重要。约翰霍普金斯大学的团队关注的是翻译过程出现问题引发的核糖体碰撞,激活核糖毒性应激反应(Ribotoxic stress response, RSR)。他们发现 ZAKα 会
Metabolic Labeling and Immunoprecipitation of Drosophila Proteins
in PBS (store up to 24 hr at 4°C) Specific antibody against protein of interest IP wash buffer: 0.1% (v/v) Triton X‐100
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