- ￥2260
- LSM Bio
- 进口
- PAab09439
- 2025年07月15日
- ELISA,WB,IF,IP
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
vacuolar protein sorting 35 homolog (S. cerevisiae)
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
O95498
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IF,IP
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
vacuolar protein sorting 35 homolog (S. cerevisiae)
- 抗体英文名：
anti-VPS35 antibody,VPS35 antibody
- 抗体名：
anti-VPS35 抗体,VPS35 抗体
- 规格：
100μl
VPS35抗体| VPS35 antibody
货号 PAab09439
蛋白别名 DKFZp434E1211 antibody, DKFZp434P1672 antibody, FLJ10752 antibody, FLJ13588 antibody, FLJ20388 antibody, hVPS35 antibody, Maternal embryonic 3 antibody, MEM3 antibody, Vesicle protein sorting 35 antibody, VPS35
蛋白介绍
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15078903, PubMed:15247922, PubMed:20164305). Required for endosomal localization of FAM21C (PubMed:22070227). Mediates the association of the CSC with the WASH complex via FAM21 (PubMed:22070227, PubMed:24980502, PubMed:24819384). Required for the endosomal localization of TBC1D5 (PubMed:20923837).
产品描述
anti-VPS35 antibody is a Rabbit Polyclonal antibody againstVPS35..
建议稀释比例
WB :1:200-1:2000;IP:1:200-1：2000;IF:1：10-1：100
IHC
Western blot
HepG2 cells were subjected to SDS PAGE followed by western blot withPAab09439( VPS35 Antibody) at dilution of 1:600(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验
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