- ￥2262
- LSM Bio
- 进口
- PAab06645
- 2025年07月14日
- ELISA,WB,IHC
- E. coli - derived recombinant protein
- Human, Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
POT1 protection of telomeres 1 homolog (S. pombe)
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
POT1 protection of telomeres 1 homolog (S. pombe)
- 抗体英文名：
anti-POT1 antibody,POT1 antibody
- 抗体名：
anti-POT1 抗体,POT1 抗体
- 规格：
100μg
POT1抗体| POT1 antibody
货号 PAab06645
蛋白别名
蛋白介绍
Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA- binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'- TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity.
产品描述
anti-POT1 antibody is a Rabbit Polyclonal antibody againstPOT1..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human prostate cancer using PAab06645(POT1 antibody) at dilution of 1:100
Western blot
HeLa cells were subjected to SDS PAGE followed by western blot with PAab06645(POT1 antibody) at dilution of 1:500(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验Human Telomere POT1-TPP1 Complex and Its Role in Telomerase Activity Regulation
Telomeres, the specialized DNA-protein complexes found at the termini of all linear eukaryotic �chromosomes, protect chromosomes from degradation and end-to-end fusion. The protection of telomeres 1 (POT1) protein binds the single-stranded
以下是我构建载体的思路，但自己心里没底，不知是否可行，请各位老师指教! 目 的：构建hPOT1正反义基因真核表达载体 材料 DH5α大肠杆菌由学校细胞生物教研室提供；含全长hPOT1 cDNA的pLPCNMyc POT1质粒由美国Rockefeller大学的de Lange教授惠赠；pcDNA-3.1(－)真核表达载体购自美国Invitrogen公司；限制性内切酶BamHⅠ、Xho Ⅰ、Nhe I、T4DNA连接酶和牛小肠碱性磷酸酶（CIP）购自美国Promag公司；超纯
Real-Time Observation of G-Quadruplex Dynamics Using Single-Molecule FRET Microscopy
The potential importance of G-quadruplex structures was implied by the recent findings that the human POT1 disrupts G-quadruplex and stimulates the telomerase activity. A solid understanding of the range of conformations that can be adopted
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