- ￥2262
- LSM Bio
- 进口
- PAab06549
- 2025年07月15日
- ELISA,IHC,WB
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
polo-like kinase 3 (Drosophila)
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,IHC,WB
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
polo-like kinase 3 (Drosophila)
- 抗体英文名：
anti-PLK3 antibody,PLK3 antibody
- 抗体名：
anti-PLK3 抗体,PLK3 抗体
- 规格：
100μg
PLK3抗体| PLK3 antibody
货号 PAab06549
蛋白别名 CNK antibody, FNK antibody, PRK
蛋白介绍
Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1.
产品描述
anti-PLK3 antibody is a Rabbit Polyclonal antibody againstPLK3..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human colon cancer using PAab06549(PLK3 antibody) at dilution of 1:10
Western blot
Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with PAab06549( PLK3 Antibody) at dilution of 1:1000(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验和细胞周期的缺失增强CD4+ T细胞功能障碍是人免疫缺陷病毒（HIV）感染人以及猿免疫缺陷病毒（SIV）感染猕猴（RM）的一种结果。已经证明在HIV和SIV体内和体外感染以后，细胞周期的M期都出现了调控障碍。 本实验研究SIV感染对M期的两个重要调节子－有丝分裂激酶Plk3和Plk1的影响。作者前期已证实SIV感染的易染病的RM中CD4+ T细胞的Plk3蛋白有明显下调而SIV感染的抗病乌白眉猴（SM）CD4+ T细胞的Plk3蛋白无下调，表示Plk3的下调与染病过程有关。 本文中，来自无SIV
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