- ￥2650
- LSM Bio
- 进口
- PAab05442
- 2025年07月15日
- ELISA,WB
- E. coli - derived recombinant protein
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
muscle, skeletal, receptor tyrosine kinase
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P15248
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
muscle, skeletal, receptor tyrosine kinase
- 抗体英文名：
anti-MUSK antibody,MUSK antibody
- 抗体名：
anti-MUSK 抗体,MUSK 抗体
- 规格：
100μg
MUSK抗体| MUSK antibody
货号 PAab05442
蛋白别名
蛋白介绍
Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity).
产品描述
anti-MUSK antibody is a Rabbit Polyclonal antibody againstMUSK..
建议稀释比例
IHC
Western blot
(本抗体仅供体外科研用途，不可用于临床诊断!) <"">
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文献和实验麝和麝香猫身上分泌麝香（musk为麝的分泌物，civet为香猫的分泌物）的腺体。都见于附属于生殖器的麝香囊中。麝的麝香囊是位于雄体腹部脐后方鸡蛋大的囊，麝香猫的麝香囊无论雌雄都位于生殖器和肛门之间。麝香可用作香料，形成这种香料香味的基本物质，麝的称麝香酮（muscone），麝香猫的称香猫酮（civetone）。
十足目短尾次目关公蟹科的 1属。中型蟹类。头胸甲长大于宽，背面有沟痕和隆起，尤如中国古典戏剧中的关公脸谱，故称关公蟹，俗名鬼脸蟹。关公蟹科是世界海洋广布的一个类群，该科在中国近海约有19种。关公蟹属额窄,具2齿。充分发育的雄性螯足一般左右不对称，而雌性的螯足和未充分发育的雄性螯足对称。步足各节扁平，前两对步足长，后两对短小，似钳状，位于背面。最大头胸甲长度约30毫米。 关公蟹主要栖息于水深8～120米的浅海底上，常用后两对步足钩住一片贝壳或其他物体置于背部，每当受惊
MuSK: A Kinase Critical for the Formation and Maintenance of the Neuromuscular Junction
Muscle-specific kinase (MuSK) is a RTK that is specifically expressed in skeletal muscle fibers and critical for the formation and maintenance of the neuromuscular junction (NMJ), a peripheral synapse formed between motoneurons
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