- ￥2650
- LSM Bio
- 进口
- PAab00942
- 2025年07月14日
- ELISA,WB,IHC,IP
- E. coli - derived recombinant protein
- Human, Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
breast cancer 1, early onset
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9GZT9
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC,IP
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
BRCA1
- 抗体英文名：
anti-BRCA1 antibody,BRCA1 antibody
- 抗体名：
anti-BRCA1 抗体,BRCA1 抗体
- 规格：
100μg
BRCA1抗体| BRCA1 antibody
货号 PAab00942
蛋白别名 RNF53
蛋白介绍
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator (PubMed:20160719).
产品描述
anti-BRCA1 antibody is a Rabbit Polyclonal antibody againstBRCA1..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human breast cancer using PAab00942(BRCA1 antibody) at dilution of 1:100
Western blot
human testis tissue were subjected to SDS PAGE followed by western blot with PAab00942(BRCA1 antibody) at dilution of 1:1000(本抗体仅供体外科研用途，不可用于临床诊断!)
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文献和实验Development of a Scoring System to Screen for BRCA1/2 Mutations
Selection for genetic testing for pathogenic mutations in BRCA1 and BRCA2 is an important area of healthcare. While testing costs for mutational analysis are falling, costs of tests in North America remain in excess of $3,000. Most countries
Developing Functional Assays for BRCA1 Unclassified Variants
Women with a family history of breast cancer have mutations in one of the breast cancer susceptibility genes, BRCA1 or BRCA2 . Since the discovery of these two genes, around 100,000 women worldwide have undergone genetic testing
Ovarian Cancer Gene Therapy with BRCA1An Overview
The human breast and ovarian cancer susceptibility gene BRCA1 is a tumorsuppressor gene which is mutated and lost in hereditary breast and ovarian cancer, and has both alleles mutated in approximately 10-15% of cases of sporadic ovarian cancer
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