InvivoCrown In vivo blocking of PD-1/PD-L signaling, Flow cytometry, Immunohistochemistry(Frozen), Western blot IV0107-1mg
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InvivoCrown In vivo blocking o

f PD-1/PD-L signaling, Flow cytometry, Immunohistochemistry(Frozen), Western blot IV0107-1mg
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  • 询价
  • InvivoCrown
  • 英国
  • IV0107-1mg
  • 2025年07月12日
  • 程序性死亡蛋白1(PD-1),也称为CD279,是一种50-55 kD的糖蛋白,属于CD28家族的免疫球蛋白超家族。PD-1在CD4和CD8胸腺细胞以及激活的T细胞、B细胞和髓系细胞上短暂表达。与克隆RMP1-14和J43抗体类似,29F.1A12抗体已被证明能够在体内阻断PD-1与其配体的结合。
  • 程序性死亡蛋白1(PD-1),也称为CD279,是一种50-55 kD的糖蛋白,属于CD28家族的免疫球蛋白超家族。PD-1在CD4和CD8胸腺细胞以及激活的T细胞、B细胞和髓系细胞上短暂表达。与克隆RMP1-14和J43抗体类似,29F.1A12抗体已被证明能够在体内阻断PD-1与其配体的结合。
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原

      小鼠

    • 亚型

      大鼠

    • 形态

      该抗小鼠PD-1(CD279)体内抗体, 克隆号29F.1A12的免疫原请参考该产品说明书

    • 保存条件

      当储存于2-8°C时,此抗体至少在2个月内是稳定的。对于长期储存,应分装原液并储存在-20°C或-80°C。避免反复冻融。

    • 克隆性

      该抗小鼠PD-1(CD279)体内抗体, 克隆号29F.1A12的免疫原请参考该产品说明书

    • 标记物

      In vivo blocking of PD-1/PD-L signaling, Flow cytometry, Immunohistochemistry(Frozen), Western blot

    • 适应物种

      小鼠

    • 保质期

      当储存于2-8°C时,此抗体至少在2个月内是稳定的。对于长期储存,应分装原液并储存在-20°C或-80°C。避免反复冻融。

    • 抗原来源

      大鼠

    • 库存

      5

    • 供应商

      艾美捷

    • 宿主

      程序性死亡蛋白1(PD-1),也称为CD279,是一种50-55 kD的糖蛋白,属于CD28家族的免疫球蛋白超家族。PD-1在CD4和CD8胸腺细胞以及激活的T细胞、B细胞和髓系细胞上短暂表达。与克隆RMP1-14和J43抗体类似,29F.1A12抗体已被证明能够在体内阻断PD-1与其配体的结合。

    • 应用范围

      程序性死亡蛋白1(PD-1),也称为CD279,是一种50-55 kD的糖蛋白,属于CD28家族的免疫球蛋白超家族。PD-1在CD4和CD8胸腺细胞以及激活的T细胞、B细胞和髓系细胞上短暂表达。与克隆RMP1-14和J43抗体类似,29F.1A12抗体已被证明能够在体内阻断PD-1与其配体的结合。

    • 浓度

      In vivo blocking of PD-1/PD-L signaling, Flow cytometry, Immunohistochemistry(Frozen), Western blot

    • 靶点

      大鼠

    • 抗体英文名

      InVivoPro Anti-Mouse PD-1(CD279) in vivo antibody, Clone 29F.1A12

    • 抗体名

      抗小鼠PD-1(CD279)体内抗体, 克隆号29F.1A12

    InVivoPro Rat IgG2b in vivo Isotype controlInVivoPro Anti-Mouse PD-1(CD279) in vivo antibody, Clone 29F.1A12Rat IgG2bRat IgG2a/29F.1A12/PD-1/Programmed Death-1, CD279, PD-1/IV0105 or Rat IgG2a Isotype Control PBS, pH 7.2, contains no stabilizers or preservativesPBS, pH 7.2, contains no stabilizers or preservatives/MouseRatRat/200-500 μg per mouse; or 10 mg/kg. This range is based off the most recent publication data using the 29F.1A12 clone in vivo. Each investigator should determine their own optimal working dilution for specific applications./131/Sade-Feldman, Moshe et al. "Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma",Cell 175.4 (2018): 998-1013.e20. Zhang, Lei et al. "Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer",Cell 181.2 (2020): 442-459.e29. Soula, Mariluz et al. "Glycosphingolipid Synthesis Mediates Immune Evasion in KRAS-driven Cancer",Nature 633.8029 (2024): 451-458./Programmed death-1 (PD-1), also know as CD279 is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. Like the clones RMP1-14 and J43 antibodies, the 29F.1A12 antibody has been shown to block the binding of PD-1 to its ligands in vivo.Isotype Control in most in vivo and in vitro applicationsIn vivo blocking of PD-1/PD-L signaling, Flow cytometry, Immunohistochemistry(Frozen), Western blotprotein A or Gprotein A or GThis antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles.This antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles.2-8°C with blue ice2-8°C with blue iceLot specific, generally ≥ 5.0 mg/mlLot specific, generally ≥ 5.0 mg/ml12 months from the date of receipt if stored as recommended12 months from the date of receipt if stored as recommendedPBS Buffer, PH 7.2, with no carrier protein, or preservatives.PBS Buffer, PH 7.2, with no carrier protein, or preservatives.0.2 μM filtered0.2 μM filtered≤ 1.0 EU/mg, by the LAL method≤ 1.0 EU/mg, by the LAL method0.990.99可替换BioXCell产品货号为BE0273

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    该产品被引用文献
    抗小鼠PD-1(CD279)体内抗体, 克隆号29F.1A12,InVivoPro Anti-Mouse PD-1(CD279) in vivo antibody, Clone 29F.1A12
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    InvivoCrown In vivo blocking of PD-1/PD-L signaling, Flow cytometry, Immunohistochemistry(Frozen), Western blot IV0107-1mg
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