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- 142417
- 美国
- 2025年07月12日
- 免疫荧光，流式
- 大鼠
- 小鼠
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
APC anti-mouse CD169 (Siglec-1)
- 抗体英文名：
APC anti-mouse CD169 (Siglec-1)
- 浓度：
0.2 mg/ml
- 应用范围：
免疫荧光，流式
- 宿主：
大鼠
- 供应商：
上海善然生物
- 库存：
现货
- 抗原来源：
大鼠
- 保质期：
2-3年左右
- 适应物种：
小鼠
- 标记物：
APC
- 克隆性：
单克隆
- 保存条件：
2-8度
- 形态：
液体
- 规格：
25ug
APC anti-mouse CD169 (Siglec-1) Antibody
3D6.112
Catalog# / Size 142417 / 25 µg
142418 / 100 µg
Clone
Regulatory Status RUO
Other Names Sialic acid binding Ig-like lectin 1 (Siglec-1), Sialoadhesin (Sn)
Isotype Rat IgG2a, κ
Description CD169, also known as Siglec-1 and Sialoadhesin (Sn), is a type I lectin containing 17
immunoglobulin (Ig) domains (one variable domain and 16 constant domains). CD169 binds to
sialic acids, which can be found on PSGL-1, CD43, CD206, and CD227. By its affinity to α2, 3-
linked sialic acid, it is involved in macrophage binding to different cell types such as granulocytes,
monocytes, NK, B, and T cells. CD169 was initially identified as a sialic acid-dependent sheep
erythrocyte receptor (SER) on resident bone marrow cells of mice. It has been identified as highly
expressed on resident bone marrow macrophages which plays an important role in retention of
stem cells in mesenchymal stem cell niche. It is also found on some specific subsets of tissue
macrophages in spleen, lymph nodes, bone marrow, liver, colon, lungs, and cancer cells.
Evidence suggest that CD169-positive macrophages serve as lymph node-resident APCs to
dominate early activation of tumor antigen-specific CD8 T cells and invariant NK cell. +
Product Details
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Rat
Immunogen Purified Native Sialoadhesin from spleen
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography and conjugated with APC under optimal
conditions.
Concentration 0.2 mg/ml
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged
exposure to light. Do not freeze
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分别利用 CD3 与 CD28 的功能学抗体，以及 CD3/CD28 Streptamer® 激活扩增 T 细胞的实验步骤与实验结果。 CD3/CD28抗体法 1、实验步骤： 1.1 抗体包被 用无菌 PBS 将 anti-mouse CD3 抗体（克隆号：145-2C11）稀释至 5μg/ml，稀释后的抗体加入到 24 孔板中，每孔 400μl，4°C 包被过夜。（注：板子在加入抗体之前，先用无菌 PBS 润洗 2-3 遍，避免干孔）； 1.2 小鼠脾脏淋巴细胞分离（次日） 1. 将 70μm
Purification of Immature CD4+CD8+ Thymocytes by Panning with Anti-CD8 Antibody
Most T lymphocytes of the immune system differentiate within the thymus along the CD4/CD8 developmental pathway by a highly ordered process termed thymic selection ( 1 , 2 ). The maturation status of thymocytes is commonly assessed
流式课堂 | 易被忽略的 CD4、CD8 共表达细胞——胸腺淋巴细胞
做过流式实验的同学，对 CD4、CD8 这两个指标都不会陌生。检测 CD4+ T 细胞和 CD8+ T 细胞分型，是流式中最常见的实验之一。 通常，我们会先检测 CD3，来圈总T淋巴细胞，再分别用 CD4 抗体和 CD8 抗体，来区分 CD4+ T 淋巴细胞（辅助或调节性T细胞）和 CD8+ T 淋巴细胞（细胞毒性 T 细胞）。 新生小鼠脾脏细胞 上图为新生小鼠脾脏细胞进行的 CD3-PE、CD4-FITC、CD8-APC 三色流式实验结果。从图中可以看出，在新生小鼠脾脏中，绝大
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