huayun / IL-4Rα/ CD124 (C-mFc), Human, Recombinant,HYPC5200

huayun / IL-4Rα/ CD124 (C-mFc)

, Human, Recombinant,HYPC5200
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  • ¥4140
  • 华韵生物(Huayunbio)
  • HYPC5200
  • 2025年07月15日
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    • 详细信息
    • 技术资料
    • 供应商

      广州华韵生物科技有限公司

    • 规格

      10µg

    产品信息

    别名Interleukin-4 Receptor subunit alpha; IL-4 Receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; CD124; IL-4-binding Protein; IL4-BP; IL4R; IL4RA
    物种Human
    表达宿主Human Cells
    序列信息Met26-Gln231
    检索号P24394
    分子量50.2 kDa
    表观分子量65-86 kDa
    生物活性 Loaded Human IL-4-His on HIS1K Biosensor, can bind Human IL-4RA-mFc with an affinity constant of 0.12 nM as determined in BLI assay.

    产品特性

    纯度 >95% as determined by reducing SDS-PAGE.
    内毒素< 1.0 EU per µg as determined by LAL test.
    保存 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2~8℃ for 2~7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
    运输 Ambient temperature or ice pack.
    制剂Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
    复融Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

    背景介绍

    Interleukin 4 Receptor alpha (IL4-Ra) is a widely expressed 140 kDa transmembrane glyco Protein in theclass I Cytokine Receptor family. Mature human IL4-Ra consists of a 207 amino acid (aa) extracellulardomain (ECD) that contains a Cytokine binding region and one fibronectin type III domain, a 24 aatransmembrane segment, and a 569 aa cytoplasmic domain that contains one Box 1 Motif and one ITIMMotif. IL4-Ra plays an important role in Th2-biased immune responses, alternative macrophage activation,mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. Soluble forms of IL4-Ra,generated by alternate splicing or proteolysis, retain Ligand binding properties and inhibit IL-4 bioactivity.

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