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文献和实验Analysis of the Role of the AMP-Activated Protein Kinase in the Response to Cellular Stress
The AMP-activated protein kinase (AMPK) is the central component of a protein kinase cascade that is activated by cellular stresses causing ATP depletion and has been referred to as a “fuel gauge” or “metabolic sensor” of the eukaryotic cell
三句话读懂一篇 CNS：咖啡竟可降低心律失常风险；转入肥胖基
AMPK（AMP-activated protein kinase）是细胞内最重要的能量感受器和调节器，其功能失常会导致人体罹患肥胖、糖尿病等疾病。2021 年 7 月 23 日，美国温安洛研究所（Van Andel Institute）KarstenMelcher 课题组联合中国科学院上海药物研究所徐华强等多个课题组在 Science 杂志发表论文 Structure of an AMPK complex in its inactive, ATP-bound state。利用 Cryo-EM 技术
Metabolomics-Edited Transcriptomics Analysis (META)
metabolomic analysis, and META for reconstructing metabolic pathways and for discerning their regulatory pathways. The first example describes a hypothetical investigation on the role of a “master” metabolic switch (AMP-activated protein kinase or AMPK
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