- ￥2450
- AntibodySystem
- France
- RHB86919
- 2025年07月15日
- IF, IHC, WB
- Mouse
- Human
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- 文献和实验
- 技术资料
- 亚型：
IgG1
- 形态：
Liquid
- 保存条件：
0.01M PBS, pH 7.4, 0.5% BSA, 0.05% Sodium Azide and 50% Glycerol.
- 克隆性：
Monoclonal
- 适应物种：
Human
- 保质期：
1 year
- 级别：
科研级
- 库存：
99999
- 供应商：
AntibodySystem
- 宿主：
Mouse
- 应用范围：
IF, IHC, WB
- 浓度：
1 mg/ml
- 靶点：
HER1, Receptor tyrosine-protein kinase erbB-1, Proto-oncogene c-ErbB-1, Epidermal growth factor receptor, EGFR, ERBB1, ERBB
- 抗体英文名：
Anti-EGFR/ERBB1/HER1 Antibody (R2W78)
- 抗体名：
Anti-EGFR/ERBB1/HER1 Antibody (R2W78)
- 规格：
100 μg
| Clonality | Monoclonal |
| Species reactivity | Human |
| Host species | Mouse |
| Isotype | IgG1 |
| Conjugation | |
| Tested applications | IF: 1:50-1:200, IHC: 1:50-1:100, WB: 1:500-1:1000 |
| Applications | IF, IHC, WB |
| Form | Liquid |
| Storage buffer | 0.01M PBS, pH 7.4, 0.5% BSA, 0.05% Sodium Azide and 50% Glycerol. |
| Concentration | 1 mg/ml |
| Purity | >95% as determined by SDS-PAGE. |
| Target | HER1, Receptor tyrosine-protein kinase erbB-1, Proto-oncogene c-ErbB-1, Epidermal growth factor receptor, EGFR, ERBB1, ERBB |
| Purification | Protein A/G purified from cell culture supernatant. |
| Endotoxin level | Please contact with the lab for this information. |
| Accession | P00533 |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| Clone ID | R2W78 |
| Note | For research use only. |
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文献和实验ERBB3/HER3最-新靶点进展：从“不可成药”到ADC与双抗ADC的分层格局
3胞内区无内在的酪氨酸激酶活性不能自身磷酸化，但ERBB3能够与表皮生长因子受体家族其它成员，ERBB1（又称EGFR，HER1）、ERBB2/HER2和ERBB4/HER4形成异源性二聚体，激活下游通路，影响细胞的增殖分化 [4]。其中ERBB3/ERBB2二聚体被认为是ERBB3二聚体中最活跃的，且活性常高于其它异源二聚体 [7]。这种异源二聚体构象使信号复合物能够激活MAPK/ERK和PI3K/AKT在内的多种通路 [8, 9]。 图2. ERBB3/ERBB2异源二聚体激活相关下游信号
) A431 cells. At 48 h after infection, these cells were stained with ten different primary antibodies (5 g/ml) specific for different cell surface markers: anti-CD15 (clone 2F3; BD, PharMingen, San Diego, CA), anti-ERBB-2 (clone SP77; ref. 5), anti-ERBB
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