CoPoP

一种含有钴卟啉的磷脂酰胆碱；已被用于生成用于捕获带有His标签的蛋白质和肽的脂质体；含有CoPoP的脂质体与HIV MPER的His标签形式结合，并包裹单磷酸脂质A，在免疫健全小鼠中诱导病毒滴度，但在无胸腺小鼠中不诱导，且通过加强注射进一步增加滴度，表明存在T细胞介导的免疫记忆反应；含有CoPoP的脂质体与其它His标签肽和其他因子结合，已被用于减少小鼠癌症模型中的肿瘤生长和转移，以及在P. falciparum诱导的小鼠疟疾模型中减少寄生虫传播，还在小鼠和兔的严重SARS-CoV-2感染模型中诱导中和抗体。A cobalt porphyrin-containing phosphatidylcholine; has been used in the generation of liposomes to capture His-tagged proteins and peptides; liposomes containing CoPoP bound to a His-tagged form of HIV MPER and encapsulating monophosphoryl lipid A induces viral titers in immunocompetent, but not athymic, mice, which is further increased by a booster injection indicating a T cell-mediated memory response; liposomes containing CoPoP bound to other His-tagged peptides and other factors have been used to reduce tumor growth and metastasis in murine cancer models and parasite transmission in a P. falciparum-induced mouse model of malaria, as well as to induce neutralizing antibodies in mice and rabbits in models of severe SARS-CoV-2 infection.分子式C57H80CoN5O9P分子量1069.2O=C(CCCCCCCCCCCCCCC)OC[C@H](COP(OCC[N+](C)(C)C)([O-])=O)OC(CC[C@@H]([C@@H]1C)C2=C(CC3=O)C4=C3C(C)=C5C=C(C(CC)=C6C)[N]7=C6C=C(C(C=C)=C8C)N9C8=CC1=[N]2[Co@]97N54)=O