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- 2025年07月11日
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文献和实验Immortalization of Human Prostate Cells With the Human Papillomavirus Type 16 E6 Gene
. With the addition of DU145 the list of human experimental prostate cell systems is almost exhausted, although recently new sets of cell lines, immortalized by viral and nonviral genes, have begun to appear to augment the list (1 –5 ).
Human Papillomavirus Detection by PCR and Typing by Dot-Blot
and (2) late-expressing genes, and (3) a noncoding upstream regulatory region (URR) (Fig. 1 ). The early region is downstream of the URR and consist of six open reading frames (ORFs) (El, E2, E4, E5, E6, and E7). El encodes a DNA binding protein involved
Analysis of E7/Rb Associations
of fundamental events, such as cell proliferation and apoptosis. The best-characterized activity of E7 from HPV type 16, the most frequently detected type in cervical cancer, is its ability to bind and induce degradation of the tumor-suppressor retinoblastoma
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