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文献和实验The Thalidomide Disaster, Lessons from the Past
It is close to 60 years since thalidomide was created by the German company, Chemie-Gr�nenthal, and launched as “Contergan.” This was soon to be followed in England by the launch of “Distaval.” Of all the drugs developed in the intervening
哺乳类缺少四肢或部分肢脚的一种畸形。完全缺乏者亦称为无肢畸形（amelia）。自然发生者相当罕见。酞胺哌啶酮（ thalidomide）具有明显的引起这种畸形的作用。
In Vivo Animal Models of Teratogenicity
Before the advent of the thalidomide tragedy, it had often been assumed that the maternal biosystems of hepatic detoxification and metabolism, together with the placental barrier, acted as a shield and were a natural protection for the embryo
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