IP01302 培美曲塞二钠水合物(10mM in Wate

Pemetrexed Disodium是一种叶酸拮抗剂。抑制胸苷酸合成酶 (TS)，二氢叶酸还原酶 (DHFR) 和甘氨酰胺核苷酸甲酰转移酶 (GARFT)。

Pemetrexed disodium hemipenta hydrate is a novel antifolate， the Ki values of the pentaglutamate of LY231514 are 1.3， 7.2， and 65 nM for inhibits thymidylate synthase (TS)， dihydrofolate reductase (DHFR)， and glycinamide ribonucleotide formyltransferase (GARFT)， respectively.[1-2]

[1]. Shih C， et al. LY231514， a pyrrolo[2，3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res. 1997 Mar 15;57(6):1116-23.
[2]. Anraku M， et al. Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignantmesothelioma. J Immunol. 2010 Jul 15;185(2):956-66.