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T25
RBL-2H3/RBL-2H3细胞系/RBL-2H3细胞株/RBL-2H3大鼠嗜碱性粒细胞性白血病细胞
Cell line name RBL-2H3
Synonyms RBL2H3; RBL 2H3; RBL.2H3
Accession CVCL_0591
Resource Identification Initiative To cite this cell line use: RBL-2H3 (RRID:CVCL_0591)
Comments Doubling time: ~50-60 hours (DSMZ=ACC-312).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Disease Rat leukemia (NCIt: C60428)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Wistar; RS=RS:0000955.
Hierarchy Children:
CVCL_C4MP (RBL SX-38) CVCL_KU64 (RBL-2H3 ADORA2A Gq) CVCL_KU65 (RBL-2H3 MRGPRX1 Gq)
CVCL_C4MQ (RBL-30/25) CVCL_C4MR (RBL-hEIalpha-2B12) CVCL_1D84 (TB1A2)
Originate from same individual CVCL_0496 ! RBL-1
Category Cancer cell line
Publications
PubMed=6166481; DOI=10.1002/eji.1830110410
Barsumian E.L., Isersky C., Petrino M.G., Siraganian R.P.
IgE-induced histamine release from rat basophilic leukemia cell lines: isolation of releasing and nonreleasing clones.
Eur. J. Immunol. 11:317-323(1981)
PubMed=6173265
Siraganian R.P., McGivney A., Barsumian E.L., Crews F.T., Hirata F., Axelrod J.
Variants of the rat basophilic leukemia cell line for the study of histamine release.
Fed. Proc. 41:30-34(1982)
PubMed=2940298; DOI=10.4049/jimmunol.136.12.4652
Okuno T., Takagaki Y., Pluznik D.H., Djeu J.Y.
Natural cytotoxic (NC) cell activity in basophilic cells: release of NC-specific cytotoxic factor by IgE receptor triggering.
J. Immunol. 136:4652-4658(1986)
PubMed=3262677; DOI=10.4049/jimmunol.141.9.3061
Richards A.L., Okuno T., Takagaki Y., Djeu J.Y.
Natural cytotoxic cell-specific cytotoxic factor produced by IL-3-dependent basophilic/mast cells. Relationship to TNF.
J. Immunol. 141:3061-3066(1988)
PubMed=17210052; DOI=10.1111/j.1365-2222.2006.02618.x
Kaul S., Luttkopf D., Kastner B., Vogel L., Holtz G., Vieths S., Hoffmann A.
Mediator release assays based on human or murine immunoglobulin E in allergen standardization.
Clin. Exp. Allergy 37:141-150(2007)
PubMed=19301096; DOI=10.1007/s00011-009-0028-4
Passante E., Ehrhardt C., Sheridan H., Frankish N.
RBL-2H3 cells are an imprecise model for mast cell mediator release.
Inflamm. Res. 58:611-618(2009)
PubMed=25149487; DOI=10.1007/978-1-4939-1173-8_8
Passante E.
Mast cell and basophil cell lines: a compendium.
Methods Mol. Biol. 1192:101-113(2014)
PubMed=36125550; DOI=10.1007/s00441-022-03687-w
Rujitharanawong C., Yoodee S., Sueksakit K., Peerapen P., Tuchinda P., Kulthanan K., Thongboonkerd V.
Systematic comparisons of various markers for mast cell activation in RBL-2H3 cells.
Cell Tissue Res. 390:413-428(2022)
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文献和实验*发表【中文论文】请标注：由博辉生物科技（广州）有限公司提供； *发表【英文论文】请标注：From Bohui Biological Technology (Guangzhou) Co., Ltd.
Bruton's tyrosine kinase (Btk) (33) NM_000061 1682-1700 AAUUGGUAAACGAUCAAGGAG RBL-2H3, WEHI-231, NALM
:215595[6] 作者首先通过对 150 个胰腺癌样本分析，发现 HOXB9 表达较高的胰腺癌患者预后较好，然后在细胞系和 PDX 模型中均发现过表达 HOXB9 可以抑制胰腺癌细胞增殖。如下图（图 7）所示，该研究发现了细胞周期和胰腺癌细胞增殖方面一种新的 DNMT1/HOXB9/RBL2/c-Myc 通路调控机制，为胰腺癌预后和治疗提供了新的治疗思路[6]。 图 7：HOXB9 抑制小鼠体内胰腺肿瘤生长[6] B-NDG 小鼠在 TCR-T 细胞治疗中的
, hematopoetic cells beta-tubulin- mouse neuronal (21) AF312873 AAGACAGAGCCAAGUGGACUC Mouse P19 Bruton's tyrosine kinase (Btk) (33) NM_000061 1682-1700 AAUUGGUAAACGAUCAAGGAG RBL-2H3, WEHI-231, NALM-6 Bruton's tyrosine kinase (Btk) (33) NM_000061 895-913
技术资料
