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文献和实验Development of Conditionally Immortalized Epithelial Cell Lines from CF and Non-CF Mice
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene are responsible for cystic fibrosis (CF) (1 ) and the primary defect in CF is the loss of cAMP-regulated anion conductance in the apical plasma membrane
Inflammatory Mediators in CF Patients
Patients with cystic fibrosis (CF) succumb to airway infection and inflammation, and determining the extent and nature of the infecting agents, as well as the extent and nature of the inflammatory response, is critical to understanding
Xenograft Model of the CF Airway
in associating cystic fibrosis (CF) defects with CFTR dysfunction, there are many unanswered questions concerning the roles of CFTR in both normal airway biology and in CF pathology. Before effective therapeutic approaches for CF lung disease will be realized
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