- 询价
- 吉满/Genomeditech
- GM-28205AB
- 中国
- 2026年09月25日
- Mouse
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- 文献和实验
- 技术资料
- 供应商：
吉满/Genomeditech
- 库存：
现货
- 靶点：
CCR8
- 克隆性：
单克隆
- 抗体英文名：
CCR8 Antibody
- 抗体名：
CCR8 抗体
- 适应物种：
Mouse
- 亚型：
IgG1
- 规格：
1 mg
CCR8在表达层面具有高度空间与功能特异性：主要富集于肿瘤内克隆扩增且高度免疫抑制活性的 Treg，而在外周 Treg、效应 T 细胞及大多数正常组织中表达极低，从而在理论上为“精准清除肿瘤 Treg、保留外周免疫耐受”提供了可能。
其表达受到 TCR 信号及 IL-2、IL-33 等细胞因子诱导，通常被视为肿瘤反应性Treg的关键特征分子，使得靶向 CCR8 能更聚焦于“肿瘤驱动型”免疫抑制环节。
在作用机制上，CCR8抗体通过增强 ADCC/ADCP 等 Fc 介导效应，实现对肿瘤浸润 Treg 的选择性清除，同时尽可能减少对效应 T 细胞的影响。
基于这一机制逻辑，CCR8 靶向策略被认为有望在不破坏全身免疫稳态的前提下，重塑肿瘤局部免疫抑制微环境，为后续免疫治疗策略提供更具针对性的“免疫解除封锁”手段。
为了支持肿瘤免疫检查点相关研究，吉满生物提供相关体内实验级小鼠抗体。
产品简介
Expression System CHO
Aggregation < 5% as determined by SEC-HPLC
Purity >95% as determined by SDS-PAGE
Endotoxin <1 EU/mg, determined by LAL gel clotting assay
Sterility 0.2 μm Filtered
Target CCR8
Clone /
Alternative Names CY6; TER1; CCR-8; CKRL1; CDw198; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8
Sourcellsotype Monoclonal Mouse IgG2a, κ
Application Flow cytometry; CDX model
Description CCR8, also known as ChemR1, TER1, and CKR-L1, belongs to the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. CCR8 is expressed on some subsets of T cells, monocytes, macrophages, eosinophils, thymocytes, Langerhans cells, neurons, and vascular smooth muscle cells. Binding with its ligand CCL1, CCR8 plays a role in the regulation of monocyte chemotaxis and thymic cell apoptosis. It has been reported that CCR8 is also a receptor for CCL18. CCR8 is also believed to be an alternative coreceptor to CD4 for HIV-1 infection.
Formulation Phosphate-buffered solution, pH 7.2.
数据展示
GM-28205AB-1mg 1mg
GM-28205AB-5mg 5mg
GM-28205AB-25mg 25mg
GM-28205AB-50mg 50mg
GM-28205AB-100mg 100mg
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