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- BPS Bioscience
- BPS-60510
- 美国
- 2025年07月12日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
100
- 供应商：
艾美捷科技
- 英文名：
ISRE Reporter-HEK293 Recombinant Cell Line (JAK pathway)
- 规格：
2 vials
ISRE 报告基因-HEK293 重组细胞系（JAK 通路），ISRE Reporter-HEK293 Recombinant Cell Line (JAK pathway) ，ISRE 报告基因-HEK293 重组细胞系（JAK 通路）,ISRE Reporter-HEK293 Recombinant Cell Line (JAK pathway)
ISRE 报告基因-HEK293 重组细胞系（JAK 通路）-ISRE Reporter-HEK293 Recombinant Cell Line (JAK pathway)
产品货号：BPS-60510
产品规格：2 vials
JAK(Januskinase)/STAT(SignalTransducerandActivatorofTranscription)通路被多种细胞因子和生长因子激活，在细胞生长、造血和免疫反应中起重要作用。在哺乳动物中，有四种JAKs(JAK1，JAK2，jak3和TYK2)和七种STAT蛋白。干扰素α(IFNα)与其受体的结合导致jak1和tyk2的激活，其反过来磷酸化并激活stat1和STAT2。磷酸化的stat1和2形成异二聚体并与IRF9/p48结合，形成称为isgf3的蛋白质复合物。该复合物易位至细胞核并与启动子区域中的ISRE(干扰素刺激的响应元件)结合，从而促进干扰素诱导型基因的转录。
•监测ifnα诱导的活性和JAK/STAT途径活性。
•筛选JAK/STAT信号通路的激活剂或抑制剂。
ISRE 报告基因-HEK293 重组细胞系（JAK 通路）-ISRE Reporter-HEK293 Recombinant Cell Line (JAK pathway) 收到后立即储存在液氮中。
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