L6细胞

L6/L6细胞系/L6细胞株/L6大鼠骨骼肌成肌细胞

Cell line name L6

Synonyms L-6; L-6 myoblast

Accession CVCL_0385

Resource Identification Initiative To cite this cell line use: L6 (RRID:CVCL_0385)

Comments Transformant: ChEBI; CHEBI:34342; 3-methylcholanthrene (3-MC; 20-methylcholanthrene; 20-MC; MCA).

Anecdotal: Called L6 by David Yaffe because he and Sara Neuman established the cell line during the Six-Day war in 1967 (PubMed=33117511).

Derived from site: In situ; Skeletal muscle; UBERON=UBERON_0001134.

Cell type: Myoblast; CL=CL_0000056.

Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)

Hierarchy Children:

CVCL_0P25 (L6-GLUT-4myc) CVCL_3834 (L6.C10) CVCL_3835 (L6.C11)

CVCL_3836 (L6.G8) CVCL_3837 (L6.G8.C5) CVCL_C569 (L6A4)

CVCL_3387 (L6C5) CVCL_C570 (L6C9) CVCL_UI07 (L6Cl1)

CVCL_UI08 (L6Cl2) CVCL_UI09 (L6Cl5) CVCL_UI10 (L6Cl6)

CVCL_C8RC (L6E) CVCL_0386 (L6E9) CVCL_3388 (L6H2)

CVCL_6F18 (L6J1) CVCL_C565 (L6TG)

Sex of cell Male

Age at sampling 1D

Category Transformed cell line

Publications

PubMed=5245982; DOI=10.1073/pnas.61.2.477; PMCID=PMC225183

Yaffe D.

Retention of differentiation potentialities during prolonged cultivation of myogenic cells.

Proc. Natl. Acad. Sci. U.S.A. 61:477-483(1968)

 

PubMed=5481965; DOI=10.1016/S0012-1606(70)80004-5

Richler C., Yaffe D.

The in vitro cultivation and differentiation capacities of myogenic cell lines.

Dev. Biol. 23:1-22(1970)

 

PubMed=7297605; DOI=10.1016/0014-4827(81)90032-X

Parfett C.L.J., Jamieson J.C., Wright J.A.

A correlation between loss of fusion potential and defective formation of mannose-linked lipid intermediates in independent concanavalin A-resistant myoblast cell lines.

Exp. Cell Res. 136:1-14(1981)

 

PubMed=1311324; DOI=10.1016/S0021-9258(18)42923-7

Mitsumoto Y., Klip A.

Development regulation of the subcellular distribution and glycosylation of GLUT1 and GLUT4 glucose transporters during myogenesis of L6 muscle cells.

J. Biol. Chem. 267:4957-4962(1992)

 

PubMed=10484371; DOI=10.1152/ajpendo.1999.277.3.E572

Ueyama A., Yaworsky K.L., Wang Q.-H., Ebina Y., Klip A.

GLUT-4myc ectopic expression in L6 myoblasts generates a GLUT-4-specific pool conferring insulin sensitivity.

Am. J. Physiol. 277:E572-E578(1999)

 

PubMed=33117511; DOI=10.4081/ejtm.2020.9306; PMCID=PMC7582454

Yablonka-Reuveni Z., Stockdale F.E., Nudel U., Israeli D., Blau H.M., Shainberg A., Neuman S., Kessler-Icekson G., Krull E.M., Paterson B., Fuchs O.S., Greenberg D., Sarig R., Halevy O., Ozawa E., Katcoff D.J.

Farewell to professor David Yaffe -- a pillar of the myogenesis field.

Eur. J. Transl. Myol. 30:9306.1-9306.16(2020)