CaSki细胞

CaSki人宫颈癌肠转移细胞/人宫颈癌上皮细胞Cell line name Ca Ski

Synonyms Ca-Ski; CaSki; Caski; CASKI

Accession CVCL_1100

Resource Identification Initiative To cite this cell line use: Ca Ski (RRID:CVCL_1100)

Comments Group: Space-flown cell line (cellonaut).

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).

Population: Caucasian.

Virology: Contains from 100 to 800 copies of the HPV16 genome; some complete and others truncated.

Doubling time: 3.2 days (PubMed=29156801).

Microsatellite instability: Stable (MSS) (Sanger).

Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).

Omics: CNV analysis.

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: Metastatic; Small intestine; UBERON=UBERON_0002108.

PubMed=3029430; DOI=10.1128/JVI.61.4.962-971.1987; PMCID=PMC254051

Baker C.C., Phelps W.C., Lindgren V., Braun M.J., Gonda M.A., Howley P.M.

Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines.

J. Virol. 61:962-971(1987)

 

PubMed=3371749; DOI=10.1016/0090-8258(88)90029-7

Grenman S.E., Shapira A., Carey T.E.

In vitro response of cervical cancer cell lines CaSki, HeLa, and ME-180 to the antiestrogen tamoxifen.

Gynecol. Oncol. 30:228-238(1988)

 

PubMed=7751322; DOI=10.1007/BF01366967

Rantanen V., Grenman S.E., Kulmala J., Grenman R.

The intrinsic radiosensitivity and sublethal damage repair capacity of five cervical carcinoma cell lines tested with the 96-well-plate assay.

J. Cancer Res. Clin. Oncol. 121:230-234(1995)

 

CLPUB00481

Kuno H., Yoshida T.

Detection of human papillomavirus types 16, 18, and 33 in cell lines derived from human genital organs by polymerase chain reaction.

Res. Commun. Inst. Ferment. 18:6-12(1997)

 

PubMed=9887230; DOI=10.1006/gyno.1998.5194

Rantanen V., Grenman S.E., Kurvinen K., Hietanen S.H., Raitanen M., Syrjanen S.M.

p53 mutations and presence of HPV DNA do not correlate with radiosensitivity of gynecological cancer cell lines.

Gynecol. Oncol. 71:352-358(1998)

 

PubMed=10423141; DOI=10.1099/0022-1317-80-7-1725

Meissner J.D.

Nucleotide sequences and further characterization of human papillomavirus DNA present in the CaSki, SiHa and HeLa cervical carcinoma cell lines.

J. Gen. Virol. 80:1725-1733(1999)

 

PubMed=15531914; DOI=10.1038/sj.onc.1208235

Baldus S.E., Schwarz E., Lohrey C., Zapatka M., Landsberg S., Hahn S.A., Schmidt D., Dienes H.-P., Schmiegel W.H., Schwarte-Waldhoff I.

Smad4 deficiency in cervical carcinoma cells.

Oncogene 24:810-819(2005)

 

PubMed=17311676; DOI=10.1186/1471-2164-8-53; PMCID=PMC1805756

Kloth J.N., Oosting J., van Wezel T., Szuhai K., Knijnenburg J., Gorter A., Kenter G.G., Fleuren G.J., Jordanova E.S.

Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex genetic alterations in cervical cancer.

BMC Genomics 8:53.1-53.13(2007)

 

PubMed=17611311

Yang C., Li G.-C., Li Y.-H., Hu J.-Y., Xiao Y., Zhang Z.-J.

Biological properties of Caski cell lines induced by exposing to the space environment.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 32:380-386(2007)

 

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

 

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662

Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Cancer Res. 70:2158-2164(2010)