- ￥10333.05
- Sigma-Aldrich
- H4381
- made in USA
- 2025年10月19日
12 年金牌会员
企业认证
相关产品推荐更多 >
Tocris货号0821现货ICI 118,551 hydrochloride上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商
￥13678.01
Sigma货号721336-1g现货L-乳酸钠-3-13C溶液19121878899上海睿安生物Sigma官方正式授权代理商
￥10097.09
LY-294,002 hydrochloride抑制剂Sigma货号L9908现货13611631389上海睿安生物
￥2627.40
Sigma货号86247-100g现货α-淀粉酶19121878899上海睿安生物
￥4359.61
Sigma货号T1443-5mg吡啶(TCPOBOP)上海睿安生物13611631389
￥979.13
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 库存：
100⁺瓶
- 英文名：
6-Hydroxydopamine hydrochloride
- CAS号：
28094-15-7
- 保质期：
1年
- 供应商：
上海睿安生物13611631389
- 保存条件：
Room Temperature
- 规格：
1g/瓶
Sigma货号H4381现货6-羟基多巴胺盐酸盐13611631389上海睿安生物
Sigma货号H4381-100mg，¥1714.02元/瓶
Sigma货号H4381-500mg，¥6695.18元/瓶
Sigma货号H4381-1g，¥10333.05元/瓶
[别名:2,4,5-三羟基苯乙胺 盐酸盐，2,5-二羟基酪胺 盐酸盐，2-(2,4,5-三羟基苯基)乙胺 盐酸盐，6-OHDA]
说明
一般描述
6-羟基多巴胺盐酸盐(6-OHDA)是一种神经毒素，通常用于诱导帕金森症′(PD)。6-OHDA可导致黑质致密部的多巴胺能神经元死亡，从而渐进式模仿PD。6-OHDA是高度可氧化的，其不能穿过血脑屏障。6-OHDA可通过产生活性氧物质，引发细胞应激和细胞死亡而发挥细胞毒性。在很多体外模型中，如原代神经元培养、人神经母细胞瘤细胞系、以及大鼠肾上腺嗜铬细胞瘤细胞系PC12，6-OHDA会导致许多神经元细胞的死亡。
应用
6-羟基多巴胺盐酸盐已被用于：
- 在大鼠中诱发帕金森症′(PD)
- 分析6-OHDA对PC12细胞的细胞毒性
- 诱导来自蓝斑中的去甲肾╳上╳腺╳素能(NA)神经元缺失
生化/生理作用:破坏儿茶酚胺能神经末端的神经毒素。
注意:吸湿
重悬:溶于含有0.1％偏亚╳硫╳酸╳氢╳钠或其他抗氧化剂的无氧水中。溶液应新鲜制备，并避免暴露在光线下。溶液在氧化时会变红。
同行评审论文
Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells: involvement of hydrogen peroxide-dependent and-independent action
Saito Y, et al.
Free Radical Biology & Medicine, 42(5), 675-685 (2007)
Human induced pluripotent stem cell-derived neurons improve motor asymmetry in a 6-hydroxydopamine-induced rat model of Parkinson's disease
Han F, et al.
Cytotherapy, 17(5), 665-679 (2015)
The 6-hydroxydopamine model and parkinsonian pathophysiology: Novel findings in an older model
Hernandez-Baltazar D, et al.
Neurologia (Barcelona, Spain), 32(8), 533-539 (2017)
MiR-410 exerts neuroprotective effects in a cellular model of Parkinson's disease induced by 6-hydroxydopamine via inhibiting the PTEN/AKT/mTOR signaling pathway.
Hanming Ge et al.
Experimental and molecular pathology, 109, 16-24 (2019-05-09)
Parkinson's disease (PD) is a chronic neurodegenerative disease characterized by loss of dopaminergic neurons in the substantia nigra. Recently, microRNAs (miRNAs) were emerging as important mediators in dopaminergic neuron biology. This study determined miR-410 expression in the 6-hydroxydopamine (6-OHDA)-induced in
Serotonergic system in hypoxic ventilatory response in unilateral rat model of Parkinson's disease.
Kryspin Andrzejewski et al.
Journal of biomedical science, 24(1), 24-24 (2017-03-30)
Malfunctioning of the serotonergic system in Parkinson's disease may contribute to non-motor symptoms such as respiratory complications. Thus the aim of our study was to investigate the role of serotonin 5-HT Wistar rats were lesioned unilaterally with double 6-hydroxydopamine (6-OHDA)
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验该产品被引用文献
Sigma货号H4381现货6-羟基多巴胺盐酸盐13611631389上海睿安生物
Sigma货号H4381-100mg，¥1714.02元/瓶
Sigma货号H4381-500mg，¥6695.18元/瓶
Sigma货号H4381-1g，¥10333.05元/瓶
[别名:2,4,5-三羟基苯乙胺 盐酸盐，2,5-二羟基酪胺 盐酸盐，2-(2,4,5-三羟基苯基)乙胺 盐酸盐，6-OHDA]
说明
一般描述
6-羟基多巴胺盐酸盐(6-OHDA)是一种神经毒素，通常用于诱导帕金森症′(PD)。6-OHDA可导致黑质致密部的多巴胺能神经元死亡，从而渐进式模仿PD。6-OHDA是高度可氧化的，其不能穿过血脑屏障。6-OHDA可通过产生活性氧物质，引发细胞应激和细胞死亡而发挥细胞毒性。在很多体外模型中，如原代神经元培养、人神经母细胞瘤细胞系、以及大鼠肾上腺嗜铬细胞瘤细胞系PC12，6-OHDA会导致许多神经元细胞的死亡。
应用
6-羟基多巴胺盐酸盐已被用于：
- 在大鼠中诱发帕金森症′(PD)
- 分析6-OHDA对PC12细胞的细胞毒性
- 诱导来自蓝斑中的去甲肾╳上╳腺╳素能(NA)神经元缺失
生化/生理作用:破坏儿茶酚胺能神经末端的神经毒素。
注意:吸湿
重悬:溶于含有0.1％偏亚╳硫╳酸╳氢╳钠或其他抗氧化剂的无氧水中。溶液应新鲜制备，并避免暴露在光线下。溶液在氧化时会变红。
同行评审论文
Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells: involvement of hydrogen peroxide-dependent and-independent action
Saito Y, et al.
Free Radical Biology & Medicine, 42(5), 675-685 (2007)
Human induced pluripotent stem cell-derived neurons improve motor asymmetry in a 6-hydroxydopamine-induced rat model of Parkinson's disease
Han F, et al.
Cytotherapy, 17(5), 665-679 (2015)
The 6-hydroxydopamine model and parkinsonian pathophysiology: Novel findings in an older model
Hernandez-Baltazar D, et al.
Neurologia (Barcelona, Spain), 32(8), 533-539 (2017)
MiR-410 exerts neuroprotective effects in a cellular model of Parkinson's disease induced by 6-hydroxydopamine via inhibiting the PTEN/AKT/mTOR signaling pathway.
Hanming Ge et al.
Experimental and molecular pathology, 109, 16-24 (2019-05-09)
Parkinson's disease (PD) is a chronic neurodegenerative disease characterized by loss of dopaminergic neurons in the substantia nigra. Recently, microRNAs (miRNAs) were emerging as important mediators in dopaminergic neuron biology. This study determined miR-410 expression in the 6-hydroxydopamine (6-OHDA)-induced in
Serotonergic system in hypoxic ventilatory response in unilateral rat model of Parkinson's disease.
Kryspin Andrzejewski et al.
Journal of biomedical science, 24(1), 24-24 (2017-03-30)
Malfunctioning of the serotonergic system in Parkinson's disease may contribute to non-motor symptoms such as respiratory complications. Thus the aim of our study was to investigate the role of serotonin 5-HT Wistar rats were lesioned unilaterally with double 6-hydroxydopamine (6-OHDA)
文献支持
Sigma货号H4381现货6-羟基多巴胺盐酸盐13611631389上海睿安生物
￥10333.05
