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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
2-8°C
- 保质期：
1年
- 英文名：
TCPOBOP
- 库存：
100⁺瓶
- 供应商：
上海睿安生物13611631389
- CAS号：
76150-91-9
- 规格：
5mg/瓶
Sigma货号T1443-5mg吡啶(TCPOBOP)上海睿安生物13611631389
TCPOBOP
≥98%(HPLC),solid
别名:1,4-双-[2-（3,5-二氯吡啶氧基）]苯, 3,3′,5,5′-四氯-1,4-双（吡啶氧基)苯
说明
应用:TCPOBOP已被用于增强小鼠肝癌细胞中Mcl-1-斜体启动子的功能。TCPOBOP也被用于研究组成型雄烷受体(CAR) 诱导小鼠肝细胞基因表达。
生化/生理作用
TCPOBOP 作为 CAR 的剂量依赖性直接激动剂，可增强细胞色素 P450 (CYP) 的核受体 CAR 转活。
TCPOBOP 作为 CAR 的剂量依赖性直接激动剂，可增强细胞色素 P450 (CYP) 的核受体 CAR 转活。是(běn)巴比_妥类 CYP 诱导剂中已知最有效的成分。
特点和优势
该化合物是细胞凋亡研究的特色产品。点击此处，发现更多特色细胞凋亡产品。如需了解有关生物活性小分子在其他研究领域的更多信息，请访问sigma.com/ discover-bsm。
制备说明:TCPOBOP 可溶于DMSO，浓度大于10mg/mL。不溶于水。
同行评审论文(部分文献)
Inducibility of drug-metabolizing enzymes by xenobiotics in mice with liver-specific knockout of Ctnnb1.
Albert Braeuning et al.
Drug metabolism and disposition: the biological fate of chemicals, 37(5), 1138-1145 (2009-02-25)
Basal as well as xenobiotic-induced expression of the main enzymes from phase I and phase II of drug metabolism is confined to the perivenous areas of the mammalian liver lobule. Whereas signal transduction pathways that govern xenobiotic-induced expression of these
Impact of CAR Agonist Ligand TCPOBOP on Mouse Liver Chromatin Accessibility.
Nicholas J Lodato et al.
Toxicological sciences : an official journal of the Society of Toxicology, 164(1), 115-128 (2018-04-05)
Activation of the nuclear receptor and transcription factor CAR (Nr1i3) by its specific agonist ligand TCPOBOP (1, 4-bis[2-(3, 5-dichloropyridyloxy)]benzene) dysregulates hundreds of genes in mouse liver and is linked to male-biased hepatocarcinogenesis. To elucidate the genomic organization of CAR-induced gene
Hepatitis C Virus core+1/ARF Protein Modulates the Cyclin D1/pRb Pathway and Promotes Carcinogenesis.
Savvina Moustafa et al.
Journal of virology, 92(9) (2018-02-16)
Viruses often encompass overlapping reading frames and unconventional translation mechanisms in order to maximize the output from a minimum genome and to orchestrate their timely gene expression. Hepatitis C virus (HCV) possesses such an unconventional open reading frame (ORF) within
Activation of the Akt pathway by a constitutive androstane receptor agonist results in β-catenin activation.
Andrei A Yarushkin et al.
European journal of pharmacology, 879, 173135-173135 (2020-04-28)
It is well known that activating the constitutive androstane receptor (CAR, NR1I3) leads to a significant proliferation of liver cells, which suggests that NR1I3 could be a therapeutic target for the partial resection of this organ. Studies describing NR1I3-mediated proliferative
The metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival.
Sandra Mattu et al.
Journal of hepatology, 64(4), 891-898 (2015-12-15)
l-2-Hydroxy acid oxidases are flavin mononucleotide-dependent peroxisomal enzymes, responsible for the oxidation of l-2-hydroxy acids to ketoacids, resulting in the formation of hydrogen peroxide. We investigated the role of HAO2, a member of this family, in rat, mouse and human
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文献和实验该产品被引用文献
Sigma货号T1443-5mg吡啶(TCPOBOP)上海睿安生物13611631389
TCPOBOP
≥98%(HPLC),solid
别名:1,4-双-[2-（3,5-二氯吡啶氧基）]苯, 3,3′,5,5′-四氯-1,4-双（吡啶氧基)苯
说明
应用:TCPOBOP已被用于增强小鼠肝癌细胞中Mcl-1-斜体启动子的功能。TCPOBOP也被用于研究组成型雄烷受体(CAR) 诱导小鼠肝细胞基因表达。
生化/生理作用
TCPOBOP 作为 CAR 的剂量依赖性直接激动剂，可增强细胞色素 P450 (CYP) 的核受体 CAR 转活。
TCPOBOP 作为 CAR 的剂量依赖性直接激动剂，可增强细胞色素 P450 (CYP) 的核受体 CAR 转活。是(běn)巴比_妥类 CYP 诱导剂中已知最有效的成分。
特点和优势
该化合物是细胞凋亡研究的特色产品。点击此处，发现更多特色细胞凋亡产品。如需了解有关生物活性小分子在其他研究领域的更多信息，请访问sigma.com/ discover-bsm。
制备说明:TCPOBOP 可溶于DMSO，浓度大于10mg/mL。不溶于水。
同行评审论文(部分文献)
Inducibility of drug-metabolizing enzymes by xenobiotics in mice with liver-specific knockout of Ctnnb1.
Albert Braeuning et al.
Drug metabolism and disposition: the biological fate of chemicals, 37(5), 1138-1145 (2009-02-25)
Basal as well as xenobiotic-induced expression of the main enzymes from phase I and phase II of drug metabolism is confined to the perivenous areas of the mammalian liver lobule. Whereas signal transduction pathways that govern xenobiotic-induced expression of these
Impact of CAR Agonist Ligand TCPOBOP on Mouse Liver Chromatin Accessibility.
Nicholas J Lodato et al.
Toxicological sciences : an official journal of the Society of Toxicology, 164(1), 115-128 (2018-04-05)
Activation of the nuclear receptor and transcription factor CAR (Nr1i3) by its specific agonist ligand TCPOBOP (1, 4-bis[2-(3, 5-dichloropyridyloxy)]benzene) dysregulates hundreds of genes in mouse liver and is linked to male-biased hepatocarcinogenesis. To elucidate the genomic organization of CAR-induced gene
Hepatitis C Virus core+1/ARF Protein Modulates the Cyclin D1/pRb Pathway and Promotes Carcinogenesis.
Savvina Moustafa et al.
Journal of virology, 92(9) (2018-02-16)
Viruses often encompass overlapping reading frames and unconventional translation mechanisms in order to maximize the output from a minimum genome and to orchestrate their timely gene expression. Hepatitis C virus (HCV) possesses such an unconventional open reading frame (ORF) within
Activation of the Akt pathway by a constitutive androstane receptor agonist results in β-catenin activation.
Andrei A Yarushkin et al.
European journal of pharmacology, 879, 173135-173135 (2020-04-28)
It is well known that activating the constitutive androstane receptor (CAR, NR1I3) leads to a significant proliferation of liver cells, which suggests that NR1I3 could be a therapeutic target for the partial resection of this organ. Studies describing NR1I3-mediated proliferative
The metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival.
Sandra Mattu et al.
Journal of hepatology, 64(4), 891-898 (2015-12-15)
l-2-Hydroxy acid oxidases are flavin mononucleotide-dependent peroxisomal enzymes, responsible for the oxidation of l-2-hydroxy acids to ketoacids, resulting in the formation of hydrogen peroxide. We investigated the role of HAO2, a member of this family, in rat, mouse and human
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Sigma货号T1443-5mg吡啶(TCPOBOP)上海睿安生物13611631389
￥979.13
