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- 文献和实验
- 技术资料
- 免疫原:
Synthesized peptide derived from N-terminal of Human BARD1.
- 亚型:
/
- 形态:
Liquid
- 保存条件:
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性:
Polyclonal
- 标记物:
/
- 适应物种:
Human
- 保质期:
6个月
- 抗原来源:
Homo sapiens (Human)
- 目录编号:
Q99728
- 级别:
优
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 宿主:
Rabbit
- 应用范围:
ELISA,WB;WB:1:500-1:3000
- 浓度:
>95%,The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 靶点:
BARD1
- 抗体英文名:
BARD1 Antibody
- 抗体名:
/
- 规格:
100μl
保存缓冲液
/功能
Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.Wu L.C., Nat. Genet. 14:430-440(1996).
Thai T.H., Hum. Mol. Genet. 7:195-202(1998).
Hillier L.W., Nature 434:724-731(2005).
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文献支持
BARD1抗体BARD1兔多抗抗体/抗体BARD1 Antibody抗体
¥2024






