BARD1 抗体-BARD1 Antibody

BARD1 抗体，BARD1 Antibody，BARD1 抗体,BARD1 Antibody

产品名称：BARD1 抗体-BARD1 Antibody

产品货号：PSI-16-773-50uL

产品规格：50uL

背景资料：This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

保存建议：BARD1 抗体-BARD1 AntibodyStore at -20℃

应用类型：WB

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