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文献和实验Role of Receptor Tyrosine Kinases in Lung Cancer
Lung cancer cells express receptor tyrosine kinases (RTKs) that may be important targets for therapies. RTKs are proto-oncogenes, which are key regulators for cell growth, differentiation, survival, or motility. More than 50 RTKs
HER-2/neu Oncogene Amplification Determined by Fluorescence In Situ Hybridization
The proto-oncogene HER-2/neu (C-erbB-2) has been localized to chromosome 17q and encodes a transmembrane tyrosine kinase growth factor receptor. The name for the HER-2 protein is derived from human epidermal growth factor receptor (EGFR
Preparation of Recombinant Protein Spotted Arrays for Proteome‐Wide Identification of Kinase Targets
kinase substrate identification. This approach enables the rapid determination of protein interaction networks in yeast on a proteome?wide level. The same methodology can be readily applied to higher eukaryotic systems with careful consideration
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