3,5,6,7,8,3',4'-Heptamethoxyfl

一种多甲氧基黄酮；在表达人类转运蛋白的MDCK细胞中，能够抑制BCRP外排Hoechst 33342（IC50=1.4µM）以及P-gp外排罗丹明123（IC50=31µM）；在50、100和200µg/ml的浓度下，可防止紫外线B（UVB）诱导的人皮肤成纤维细胞（HDFn）中I型前胶原的减少；抑制B16黑色素瘤4A5、CCRF-HSB-2白血病和TGBC11TKB胃癌细胞的增殖（IC50分别为38、29和9µM）；在小鼠强迫游泳实验中，以50mg/kg的剂量防止皮质酮诱导的不动时间增加。A polymethoxyflavone; inhibits the efflux of Hoechst 33342 by BCRP and rhodamine 123 by P-gp in MDCK cells expressing the human transporters (IC50s = 1.4 and 31 µM, respectively); prevents UVB-induced decreases in type I procollagen in HDFn cells at 50, 100, and 200 µg/ml; inhibits the proliferation of B16 melanoma 4A5, CCRF-HSB-2 leukemia, and TGBC11TKB gastric cancer cells (IC50s = 38, 29, and 9 µM, respectively); prevents corticosterone-induced increases in immobility time in the forced swim test in mice at 50 mg/kg.分子式C22H24O9分子量432.4O=C1C(OC)=C(C2=CC(OC)=C(OC)C=C2)OC3=C(C(OC)=C(C(OC)=C13)OC)OC