- ￥4230
- TargetMol
- 美国
- T69600
- 2025年07月16日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
Spermidine-d6
- 库存：
10
- 供应商：
TargetMol
- CAS号：
2514812-10-1
- 规格：
1 mg
Product Introduction
Bioactivity
英文名:Spermidine-d6
描述:Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay. It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan of D. melanogaster, yeast, and C. elegans. Spermidine (30 mM in the drinking water) reduces demyelination of the optic nerve and disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE). It reduces increases in blood pressure, left ventricular posterior wall thickness, and heart weight in salt-sensitive Dahl rats fed a high-salt diet, a model of hypertension-induced congestive heart failure.4 Formulations containing spermidine have been used as dietary supplements.
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文献和实验亚精胺 spermidine H2 N（ CH2 ） 3 NH（ CH2 ） 4 NH2 ，一种多胺。广泛分布在生物体内，是由腐胺（丁二胺）和腺苷甲硫氨酸生物合成的。
Assay of Spermidine and Spermine Synthases
Spermidine and spermine syntheses carry out the transfer of aminopropyl groups from decarboxylated S -adenosylmethionine (dcAdoMet) to putrescine and spermidine, respectively. Despite the close similarity of these reactions, they are totally
Spermidine/Spermine-N1-Acetyltransferase in Kidney Ischemia Reperfusion Injury
reperfusion injury and can be therapeutically targeted will lead to development of new approaches for the treatment of such injuries. The expression of spermidine/spermine-N1 -acetyltransferase increases in the kidneys subjected to ischemic reperfusion injury
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